Pharmacology thesis topics for MD/DNB

Choosing the right pharmacology thesis topics is essential for creating a meaningful and publishable postgraduate research project. Thoughtful topic selection enhances focus, facilitates deep research, and aligns with the latest pharmacological advancements.

In pharmacology, topics can span clinical pharmacology, experimental pharmacology, pharmacovigilance, pharmacogenomics, and drug development. Each category offers the opportunity to investigate real-world issues affecting patient safety and treatment efficacy. Selecting relevant pharmacology thesis topics also allows for better integration with departmental resources and access to essential datasets.

📌 Updated for 2025–2026 MD Pharmacology Thesis Topics
This Pharmacology thesis topics list is updated for the 2025–26 academic cycle. These MD Pharmacology topics are curated based on recent dissertations, examiner preferences, drug utilization patterns in Indian hospitals, and publication trends in pharmacology and clinical research journals.

High-yield and clinically relevant pharmacology research areas
Feasible studies using routine prescribing data, ADR monitoring and hospital records
Topics with good potential for publication in indexed Pharmacology and clinical journals

1. Autonomic Nervous System Pharmacology

Comparative evaluation of heart rate variability in patients treated with selective versus non-selective beta-blockers in essential hypertension.
Assessment of dry mouth and urinary retention in patients on anticholinergic drugs for overactive bladder: A cross-sectional study.
A prospective observational study on adverse drug reactions in patients receiving alpha-adrenergic blockers for benign prostatic hyperplasia.
Comparative study of incidence of postural hypotension in elderly patients on centrally acting antihypertensives versus peripherally acting agents.
Evaluation of efficacy and side effect profile of clonidine versus prazosin in the management of PTSD in a tertiary care setting.
Study on the pattern of autonomic dysfunction in patients on chronic beta-agonist therapy for asthma.
Comparative study on changes in pupil diameter and accommodation in patients treated with different antimuscarinic eye drops.
Observational study of cardiovascular adverse effects in patients receiving sympathomimetic drugs for nasal congestion.
Analysis of withdrawal symptoms in patients tapering off long-term anticholinergic therapy.
A study of pharmacokinetic interactions between beta-blockers and other commonly co-prescribed antihypertensives.

2. Cardiovascular Pharmacology

Comparative study of efficacy and tolerability of newer versus conventional diuretics in the management of congestive heart failure.
Observational study of bleeding risk in patients on dual antiplatelet therapy undergoing minor surgical procedures.
Evaluation of adherence patterns to antihypertensive medications in urban versus rural populations: A cross-sectional study.
Comparative evaluation of lipid profile changes in patients on statin monotherapy versus combination with ezetimibe.
Study on quality of life in patients on long-term anticoagulation therapy for atrial fibrillation.
Evaluation of the impact of pharmacogenomics on dosing patterns of warfarin in Indian patients.
Observational study of drug-induced arrhythmias in patients on QT-prolonging medications.
Comparative study of efficacy and side effects of ACE inhibitors versus angiotensin receptor blockers in diabetic hypertensives.
Analysis of incidence of statin-associated muscle symptoms in different age groups.
Prospective study of cardiac safety of newer oral anticoagulants in elderly patients with renal impairment.

3. Central Nervous System Pharmacology

Comparative study of sedation and cognition levels in patients receiving benzodiazepines versus zolpidem for insomnia.
Observational study of extrapyramidal symptoms in patients on long-term antipsychotic therapy.
Cross-sectional study on the pattern of drug use in patients with epilepsy in a tertiary care hospital.
Study of mood changes in patients receiving corticosteroids versus those on antidepressants for chronic inflammatory diseases.
Evaluation of incidence of serotonin syndrome in patients on combined serotonergic drugs in psychiatric practice.
A comparative study of adverse effects of first-generation versus second-generation antipsychotics in schizophrenia.
Study on the impact of antiepileptic drug therapy on reproductive hormone levels in female patients.
Observational analysis of drug compliance in Parkinson’s disease patients on levodopa-based regimens.
Comparative study on the cognitive effects of older versus newer antiepileptics in seizure-free patients.
Evaluation of long-term safety of opioid analgesics in chronic non-cancer pain patients.

4. Respiratory System Pharmacology

Comparative study of efficacy of inhaled corticosteroids versus leukotriene receptor antagonists in moderate persistent asthma.
Cross-sectional analysis of inhaler technique errors and their impact on symptom control in COPD patients.
Study on the pattern of antibiotic resistance in respiratory infections treated with macrolides.
Comparative evaluation of mucolytics versus expectorants in the symptomatic relief of chronic bronchitis.
Prospective study on the adverse effects of long-term theophylline therapy in asthma patients.
Observational study of side effects associated with prolonged corticosteroid inhalation in children.
Comparative study of salbutamol versus formoterol in prevention of exercise-induced bronchospasm.
Evaluation of patient adherence to prescribed inhaler regimens in asthma and COPD.
Analysis of emergency department visits in patients with poor compliance to bronchodilator therapy.
A prospective study on drug-drug interactions in patients with chronic respiratory diseases on polypharmacy.

5. Gastrointestinal and Hepatobiliary Pharmacology

Comparative study of proton pump inhibitors versus H2 blockers in prevention of NSAID-induced gastropathy.
Study on the incidence of hepatic enzyme elevation in patients receiving antitubercular therapy.
Observational study of adverse drug reactions associated with commonly used antiemetics.
Evaluation of impact of probiotics on antibiotic-associated diarrhea in hospitalized patients.
Comparative study of mesalazine versus sulfasalazine in ulcerative colitis management.
Cross-sectional study on the usage pattern of laxatives in elderly patients with chronic constipation.
Study of hepatotoxicity in patients receiving antiretroviral therapy with and without pre-existing liver disease.
Comparative study on the efficacy of domperidone versus metoclopramide in diabetic gastroparesis.
Observational study of drug-induced pancreatitis in patients receiving multiple medications.
Prospective study of drug-related adverse events in patients undergoing chemotherapy with hepatotoxic agents.

6. Antimicrobials and Chemotherapy

Cross-sectional study of antimicrobial prescribing patterns in tertiary care hospitals in North India.
Evaluation of nephrotoxicity associated with colistin use in multidrug-resistant infections.
Comparative study of fixed-dose combination versus individualized anti-tuberculosis therapy on treatment compliance.
Study on incidence of ototoxicity in patients receiving aminoglycosides for more than seven days.
Observational analysis of antibiotic-associated hypersensitivity reactions in pediatric versus adult patients.
Comparative efficacy of single versus multiple drug regimens in uncomplicated urinary tract infections.
Cross-sectional study of antifungal drug resistance patterns in hospital-acquired infections.
Prospective study on treatment outcomes in patients with multidrug-resistant tuberculosis on newer antitubercular drugs.
Evaluation of hepatic and renal function changes in cancer patients receiving chemotherapy.
Study on adverse drug reactions in patients undergoing empirical versus culture-based antibiotic therapy.

7. Endocrine and Metabolic Pharmacology

Observational study of hypoglycemic episodes in diabetic patients on sulfonylureas versus DPP-4 inhibitors.
Comparative study of lipid profile alterations in patients receiving different statin formulations.
Study on thyroid dysfunction in patients treated with lithium versus atypical antipsychotics.
Evaluation of vitamin D supplementation practices and biochemical responses in postmenopausal women.
Cross-sectional study of insulin injection techniques and complications in patients with type 2 diabetes.
Prospective study on weight gain and glycemic control in patients on insulin versus oral hypoglycemic agents.
Comparative analysis of metabolic syndrome parameters in patients on olanzapine versus aripiprazole.
Study of electrolyte disturbances in patients treated with diuretics for heart failure and hypertension.
Evaluation of glycemic variability and its management in ICU patients on enteral nutrition.
Observational study of polypharmacy and drug interactions in elderly diabetic patients.

8. Oncology Pharmacology

Comparative study on nausea control using ondansetron versus palonosetron in chemotherapy-induced vomiting.
Prospective observational study on adverse effects of tyrosine kinase inhibitors in chronic myeloid leukemia.
Cross-sectional study of prescription patterns of chemotherapeutic agents in a regional cancer center.
Evaluation of cognitive side effects of chemotherapy in breast cancer patients: A longitudinal study.
Comparative analysis of neutropenia and infection risk with different chemotherapy regimens.
Study of medication adherence and barriers in patients on oral anticancer drugs.
Prospective study of pharmacokinetic variability of methotrexate in pediatric leukemia patients.
Observational study on the impact of premedication protocols on hypersensitivity reactions in cancer chemotherapy.
Comparative evaluation of quality of life in patients receiving conventional versus targeted chemotherapy.
Analysis of supportive care medication use in cancer patients undergoing radiotherapy and chemotherapy.

9. Clinical Pharmacology and Therapeutics

Cross-sectional study of adverse drug reaction reporting awareness among healthcare workers in a tertiary care hospital.
Study of medication errors in prescription writing in outpatient departments.
Evaluation of drug compliance in chronic disease patients attending rural health clinics.
Comparative analysis of over-the-counter drug use between urban and rural populations.
Prospective study on the impact of pharmacovigilance education on ADR reporting among interns.
Observational study on polypharmacy and inappropriate drug use in geriatric patients.
Comparative analysis of prescribing trends in public versus private healthcare setups.
Study of patient knowledge and practices regarding antibiotic use in upper respiratory infections.
Analysis of cost-effectiveness of different antihypertensive drug regimens in public healthcare settings.
Evaluation of fixed drug combination rationality using WHO criteria in prescriptions from general practice.

10. Recent Studies in Pharmacology

Prospective study on the safety and tolerability of SGLT2 inhibitors in Indian patients with type 2 diabetes and chronic kidney disease.
Evaluation of real-world efficacy of COVID-19 oral antiviral therapies in Indian outpatients: A multicentric observational study.
Study on awareness and use of pharmacogenomics in tailoring therapy for epilepsy in tertiary care centers.
Comparative study on immunogenicity and safety of different COVID-19 vaccines used in India.
Prospective evaluation of adverse events associated with new biologics used in autoimmune diseases in Indian population.
Observational study on trends in self-medication with herbal products among medical students.
Study on emerging resistance patterns to carbapenems among Gram-negative isolates in ICU settings.
Comparative study of new oral anticoagulants versus warfarin in stroke prevention in Indian atrial fibrillation patients.
Evaluation of adverse drug reactions to newly approved drugs under emergency use authorization in India.
Cross-sectional study on the impact of pharmacovigilance software implementation on ADR reporting rates in hospitals.

Frequently Asked Questions – Pharmacology Thesis Topics (2025–2026)

1. How do I choose a feasible MD Pharmacology thesis topic for the 2025–2026 academic year?

Select a topic that matches the prescribing patterns and clinical load in your hospital. Feasible MD Pharmacology thesis topics typically include drug utilization studies, ADR monitoring, antimicrobial stewardship, fixed-dose combination analysis, pharmacoeconomics, and comparative effectiveness evaluations. Avoid molecular or lab-heavy topics unless your department has reliable access.

2. Which study designs are commonly accepted for MD Pharmacology theses?

Most MD Pharmacology theses use observational designs—cross-sectional prescription audits, retrospective or prospective drug utilization reviews, ADR and pharmacovigilance monitoring, or antimicrobial use evaluations. These are practical, ethical, and widely accepted in Indian Pharmacology departments.

3. What should I discuss with my guide before finalising a Pharmacology thesis topic?

Discuss access to prescribing data, ADR records, HIS databases, cooperation from clinical departments, expected sample size, follow-up feasibility, and total duration required. Confirm whether similar MD Pharmacology thesis topics were recently accepted in your university.

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