MICROBIOLOGY THESIS TOPICS FOR MD/DNB

MICROBIOLOGY THESIS TOPICS FOR MD/DNB

Microbiology thesis topics

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Microbiology Thesis Topics

1. Bacteriology

1.     Comparative analysis of antimicrobial susceptibility patterns in Escherichia coli isolated from community and hospital-acquired urinary tract infections.

2.     Study of biofilm formation and antibiotic resistance in Pseudomonas aeruginosa from ICU patients.

3.     Observational study on multidrug-resistant Klebsiella pneumoniae isolates from respiratory infections in a tertiary care hospital.

4.     Evaluation of extended-spectrum beta-lactamase production in Enterobacteriaceae from wound infections.

5.     Cross-sectional study of methicillin resistance in Staphylococcus aureus isolated from skin and soft tissue infections.

6.     Study of carbapenem resistance mechanisms in Acinetobacter baumannii isolates from intensive care units.

7.     Comparative evaluation of automated and manual systems for identification and susceptibility testing of gram-negative bacteria.

8.     Study of antimicrobial resistance patterns in Salmonella spp. isolated from blood culture samples.

9.     Evaluation of bacteriological profile and antibiogram in diabetic foot infections.

10.  Surveillance of bacterial pathogens in bloodstream infections in neonates and their resistance trends.

2. Virology

11.  Study of seroprevalence and clinical correlation of hepatitis B surface antigen among pregnant women attending antenatal clinic.

12.  Comparative study of dengue virus NS1 antigen detection versus IgM antibody testing for early diagnosis.

13.  Molecular typing of influenza A virus strains during seasonal outbreaks in a tertiary care center.

14.  Evaluation of cytomegalovirus DNA in immunocompromised patients using polymerase chain reaction.

15.  Study of co-infection with hepatitis B and hepatitis C virus in patients with chronic liver disease.

16.  Cross-sectional study of herpes simplex virus seropositivity in sexually transmitted disease clinic attendees.

17.  Prevalence and genotype analysis of human papillomavirus in cervical swab samples from women with abnormal cytology.

18.  Study of respiratory viral pathogens in hospitalized children with lower respiratory tract infections.

19.  Evaluation of rotavirus infection and genotyping in children with acute gastroenteritis.

20.  Serological and molecular study of HIV-1 and HIV-2 among newly diagnosed patients in a tertiary care hospital.

3. Mycology

21.  Study of candidemia in hospitalized patients: species distribution and antifungal susceptibility.

22.  Observational study of fungal isolates from chronic sinusitis and their identification using conventional and automated methods.

23.  Cross-sectional analysis of dermatophyte infections among immunocompetent and immunocompromised patients.

24.  Study of fungal pathogens in onychomycosis: morphological and molecular identification.

25.  Evaluation of Candida species from oral thrush in HIV-positive patients and their antifungal sensitivity.

26.  Comparative study of Aspergillus species identification using culture and galactomannan assay in patients with suspected invasive aspergillosis.

27.  Study of fungal elements in sputum of tuberculosis suspects using KOH and culture techniques.

28.  Evaluation of antifungal resistance in Candida albicans isolated from urinary tract infections.

29.  Study of mucormycosis in post-COVID-19 patients with diabetes mellitus.

30.  Observational study of chronic pulmonary fungal infections in patients with prior tuberculosis.

4. Parasitology

31.  Comparative study of stool microscopy versus antigen detection in diagnosis of giardiasis in pediatric patients.

32.  Study of Plasmodium falciparum and vivax infections using rapid diagnostic tests and microscopy in endemic areas.

33.  Cross-sectional study on prevalence of intestinal parasites among food handlers in institutional kitchens.

34.  Evaluation of eosinophil count and stool examination in patients with suspected helminthiasis.

35.  Study of malarial parasitemia and species identification using thick and thin blood smear and PCR.

36.  Serological evaluation of toxoplasmosis in pregnant women attending antenatal clinics.

37.  Prevalence and morphological study of filarial worms in peripheral blood samples collected at night.

38.  Comparative analysis of direct microscopy and culture in diagnosis of leishmaniasis in endemic regions.

39.  Study of Strongyloides stercoralis infection in immunocompromised individuals.

40.  Observational study on the burden of parasitic infections among slum dwellers in a metropolitan city.

5. Immunology

41.  Evaluation of C-reactive protein and procalcitonin as biomarkers in bacterial versus viral infections.

42.  Study of humoral immune response post-hepatitis B vaccination among healthcare workers.

43.  Comparative study of inflammatory cytokines in bacterial sepsis versus viral fever.

44.  Assessment of T-cell subsets in HIV-positive patients with and without opportunistic infections.

45.  Study of serum immunoglobulin levels in children with recurrent respiratory tract infections.

46.  Evaluation of delayed hypersensitivity reaction using tuberculin skin test among household contacts of TB patients.

47.  Study of anti-nuclear antibodies in autoimmune disorders presenting in outpatient clinics.

48.  Correlation of complement levels with disease activity in systemic lupus erythematosus.

49.  Observational study of allergy testing using skin prick method in patients with suspected food allergies.

50.  Cross-sectional analysis of antibody titers in vaccinated versus unvaccinated individuals against tetanus and diphtheria.

6. Clinical Microbiology and Diagnostics

51.  Evaluation of automated blood culture systems versus conventional methods in early detection of sepsis.

52.  Study of antimicrobial susceptibility testing using disk diffusion and E-test for key bacterial pathogens.

53.  Comparative analysis of MALDI-TOF and conventional biochemical methods in bacterial identification.

54.  Evaluation of the effectiveness of point-of-care tests for detection of urinary tract infections.

55.  Study of diagnostic accuracy of GeneXpert in extrapulmonary tuberculosis specimens.

56.  Cross-sectional study of microbial contamination in high-touch surfaces in hospital wards.

57.  Assessment of culture media efficacy in isolating common pathogens from clinical samples.

58.  Observational study of laboratory turnaround time and its impact on patient care in a tertiary hospital.

59.  Evaluation of multiplex PCR in detection of enteric pathogens from stool samples.

60.  Study of diagnostic methods for anaerobic bacteria from deep tissue infections.

7. Antimicrobial Resistance

61.  Surveillance of antibiotic resistance patterns in gram-negative isolates from intensive care units.

62.  Comparative study of antimicrobial resistance in community-acquired and hospital-acquired pathogens.

63.  Evaluation of resistance genes in methicillin-resistant Staphylococcus aureus isolates.

64.  Study of extended-spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from urine samples.

65.  Analysis of vancomycin-resistant Enterococcus species and their clinical implications.

66.  Observational study of multidrug-resistant organisms colonizing healthcare workers.

67.  Study of antibiogram trends in post-surgical site infections over a five-year period.

68.  Correlation of antibiotic usage patterns with resistance trends in a tertiary care hospital.

69.  Evaluation of antimicrobial resistance in non-fermenting gram-negative bacilli isolated from respiratory specimens.

70.  Study of carbapenemase production in Enterobacteriaceae using phenotypic and genotypic methods.

8. Infection Control and Hospital Epidemiology

71.  Observational study of hand hygiene compliance among healthcare workers in intensive care units.

72.  Evaluation of the effectiveness of hospital infection control training programs on staff compliance.

73.  Cross-sectional study of surgical site infection rates and associated risk factors in post-operative patients.

74.  Study of environmental sampling of hospital surfaces for nosocomial pathogens.

75.  Surveillance of catheter-associated urinary tract infections in medical wards.

76.  Study of ventilator-associated pneumonia: incidence, risk factors, and microbial profile.

77.  Evaluation of outbreak investigation methods for infection clusters in neonatal ICUs.

78.  Study of the impact of antimicrobial stewardship programs on antibiotic usage and resistance patterns.

79.  Comparative study of infection control practices in government versus private hospitals.

80.  Study of needle stick injuries among healthcare workers and assessment of post-exposure prophylaxis adherence.

9. Zoonotic and Emerging Infections

81.  Study of leptospira seroprevalence in patients with febrile illness from flood-affected areas.

82.  Cross-sectional analysis of brucellosis in livestock handlers and veterinary workers.

83.  Study of scrub typhus infection using IgM ELISA and its clinical correlation in rural populations.

84.  Evaluation of Q fever seropositivity among dairy workers and abattoir employees.

85.  Observational study of hantavirus infection risk in patients with rodent exposure history.

86.  Study of emerging multidrug-resistant Salmonella species in poultry meat samples.

87.  Seroprevalence of rabies-neutralizing antibodies among dog-bite victims receiving post-exposure prophylaxis.

88.  Study of avian influenza awareness and protective behaviors among poultry workers.

89.  Detection of chikungunya virus RNA in blood samples during outbreak situations.

90.  Comparative analysis of COVID-19 positivity in symptomatic versus asymptomatic healthcare workers.

10. Recent Studies in Microbiology

91.  Molecular characterization of colistin-resistant Klebsiella pneumoniae isolated from clinical samples.

92.  Evaluation of metagenomic sequencing for rapid diagnosis of pyogenic meningitis.

93.  Study of bacteriophage therapy potential against multidrug-resistant Pseudomonas aeruginosa.

94.  Comparative analysis of rapid antigen and RT-PCR testing in COVID-19 diagnosis.

95.  Study of fecal microbiota transplantation outcomes in patients with recurrent Clostridioides difficile infection.

96.  Evaluation of CRISPR-Cas system in detection of viral pathogens in blood samples.

97.  Observational study of long-COVID patients for secondary bacterial and fungal infections.

98.  Molecular epidemiology of SARS-CoV-2 variants in post-vaccinated breakthrough infections.

99.  Evaluation of nanoparticle-based diagnostics for tuberculosis detection in sputum samples.

100.Study of next-generation sequencing in detecting emerging fungal pathogens from blood cultures.

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