CRITICAL CARE MEDICINE THESIS TOPICS FOR MD/DNB

Research Topics

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A comparative study evaluating the diagnostic accuracy of procalcitonin versus C-reactive protein in early identification of sepsis in critically ill adult patients in Indian tertiary care hospitals.
A randomised controlled trial to assess the impact of point-of-care lactate monitoring on early detection and outcome in suspected septic patients in emergency departments.
A retrospective observational study on the role of neutrophil-to-lymphocyte ratio as a predictor of septic shock in intensive care unit admissions.
A mixed-method prospective cohort study on serial procalcitonin levels and their association with mortality in patients with bloodstream infections.
A comparative study of presepsin and interleukin-6 levels for early detection of bacterial sepsis in medical intensive care units.
A randomised controlled trial on early use of sepsis alert algorithms based on lactate and vital signs in reducing time to antibiotic administration.
A prospective observational study evaluating the diagnostic performance of soluble triggering receptor expressed on myeloid cells in differentiating sepsis from non-infective systemic inflammatory response syndrome.
A comparative study between traditional clinical scoring systems and novel biomarkers in predicting septic shock in critically ill adults.
A randomised controlled trial assessing the effectiveness of bedside sepsis screening tools in reducing diagnostic delay in rural hospital settings.
A retrospective study correlating early biomarker trends with organ dysfunction progression in patients admitted with severe sepsis.
A comparative study on outcomes of culture-guided versus empirical antibiotic therapy in patients with septic shock in intensive care units.
A randomised controlled trial evaluating the efficacy of early de-escalation of antibiotics based on day 3 culture reports in patients with severe sepsis.
A retrospective cohort study on the impact of multidrug-resistant organisms on mortality in septic patients admitted to tertiary care critical care units.
A prospective observational study evaluating the clinical outcomes of using antibiotic stewardship protocols in management of sepsis.
A comparative study of continuous infusion versus intermittent bolus of beta-lactam antibiotics in critically ill septic patients.
A randomised controlled trial comparing combination antibiotic therapy versus monotherapy in management of ventilator-associated pneumonia-related sepsis.
A retrospective analysis of inappropriate initial antibiotic use and its association with increased length of stay and mortality in septic patients.
A mixed-method study assessing compliance with antimicrobial guidelines and its effect on sepsis-related mortality in public sector ICUs.
A randomised controlled trial on the role of procalcitonin-guided discontinuation of antibiotics in critically ill patients with bacterial sepsis.
A prospective study analysing delays in antibiotic administration and their association with clinical outcomes in emergency-diagnosed septic shock patients.
A comparative study of lactate clearance versus central venous oxygen saturation as endpoints for resuscitation in septic shock.
A randomised controlled trial comparing norepinephrine versus dopamine as first-line vasopressor in Indian patients with septic shock.
A prospective observational study on the impact of early fluid resuscitation with balanced crystalloids versus normal saline on renal outcomes in septic patients.
A retrospective cohort study evaluating the effect of time-to-fluid administration on mortality in septic shock.
A randomised controlled trial comparing restrictive versus liberal fluid strategies in the management of sepsis-induced hypotension.
A comparative study evaluating the use of passive leg raising test versus central venous pressure monitoring in guiding fluid therapy in septic shock.
A prospective cohort study on vasopressor dependency index and its correlation with mortality in patients with septic shock.
A randomised controlled trial comparing fixed-dose vasopressor escalation versus dynamic titration based on mean arterial pressure in septic patients.
A retrospective analysis of vasopressor initiation timing and 28-day mortality in patients with septic shock.
A comparative study on outcomes with early versus late initiation of vasopressin in patients with catecholamine-refractory septic shock.
A randomised controlled trial evaluating early initiation versus delayed initiation of renal replacement therapy in septic acute kidney injury.
A retrospective cohort study assessing the impact of sepsis-associated liver dysfunction on duration of organ support and mortality.
A comparative study on high-flow nasal oxygen therapy versus non-invasive ventilation in sepsis-related acute hypoxemic respiratory failure.
A prospective observational study of sepsis-induced coagulopathy and the utility of viscoelastic testing in guiding transfusion.
A randomised controlled trial on the effect of low tidal volume ventilation strategy in septic patients with no acute respiratory distress syndrome.
A comparative study of conventional mechanical ventilation versus airway pressure release ventilation in sepsis-induced lung injury.
A retrospective study on the incidence of sepsis-related myocardial dysfunction and the need for inotropic support in ICU settings.
A prospective cohort study correlating changes in hepatic enzymes and outcomes in sepsis-induced liver injury.
A randomised controlled trial evaluating the impact of cytokine hemoadsorption therapy on vasopressor requirement in refractory septic shock.
A mixed-method study exploring patterns of multi-organ dysfunction and prognostic indicators in sepsis patients requiring prolonged organ support.
A comparative study of sepsis characteristics and outcomes in elderly versus younger adult patients admitted to intensive care units.
A randomised controlled trial evaluating the role of early enteral nutrition in improving outcomes in septic patients with chronic liver disease.
A prospective observational study on the clinical profile and outcomes of sepsis in patients with malignancy admitted to critical care units.
A retrospective cohort study on maternal sepsis in Indian intensive care units: patterns, pathogens and mortality predictors.
A comparative study of sepsis-related outcomes in diabetic versus non-diabetic critically ill patients.
A prospective study assessing sepsis-related complications in patients on chronic dialysis admitted with bloodstream infections.
A randomised controlled trial on early immunomodulator therapy in patients with septic shock and underlying autoimmune disorders.
A retrospective analysis of the clinical course of patients with HIV-associated sepsis in tertiary care critical care units.
A comparative study of septic shock outcomes in malnourished versus well-nourished patients admitted to intensive care.
A prospective cohort study evaluating predictors of mortality in cirrhotic patients presenting with sepsis in emergency settings.
A comparative study on outcomes of early versus delayed source control interventions in intra-abdominal sepsis in surgical intensive care units.
A randomised controlled trial assessing the utility of bedside ultrasound versus clinical examination alone in detecting occult sources of sepsis.
A prospective observational study evaluating the role of computed tomography imaging in identifying non-apparent sources of infection in sepsis patients.
A retrospective analysis of percutaneous drainage versus surgical drainage for intra-abdominal abscesses in patients with sepsis.
A randomised controlled trial comparing clinical outcomes of patients undergoing protocolised source identification versus standard care in undifferentiated sepsis.
A comparative study on the effectiveness of prompt surgical source control versus medical management in sepsis from soft tissue infections.
A prospective observational study on diagnostic yield of serial imaging for ongoing sepsis in patients with negative initial imaging.
A retrospective cohort study on timing of invasive source control and its correlation with 28-day mortality in sepsis patients.
A randomised controlled trial evaluating outcomes of early bronchoscopy-guided lavage in sepsis related to suspected lower respiratory infections.
A comparative study of sepsis outcomes in patients with central line-associated bloodstream infection managed with early versus delayed catheter removal.
A randomised controlled trial assessing the efficacy of low-dose corticosteroids in refractory septic shock in critically ill Indian patients.
A comparative study evaluating the impact of immunonutrition versus standard nutrition on immune response markers in patients with sepsis.
A prospective observational study on trends in immune cell profiles and their correlation with outcomes in septic patients.
A retrospective cohort analysis of sepsis-associated immunosuppression and its link to secondary infections in intensive care units.
A randomised controlled trial on intravenous immunoglobulin as adjunctive therapy in septic patients with multi-organ dysfunction.
A comparative study of immune response and outcomes in sepsis caused by gram-positive versus gram-negative bacterial infections.
A prospective study evaluating serum interleukin-10 and tumour necrosis factor-alpha levels as predictors of outcome in sepsis.
A retrospective analysis of delayed mortality in sepsis survivors and its association with persistent immune dysfunction.
A randomised controlled trial on immunomodulatory effect of selenium supplementation in patients with septic shock.
A comparative study of corticosteroid responsiveness in sepsis patients with and without adrenal insufficiency.
A comparative study of sequential organ failure assessment versus acute physiology and chronic health evaluation scoring systems in predicting mortality in sepsis.
A randomised controlled trial evaluating clinical decision-making guided by dynamic scoring systems in the management of sepsis.
A prospective observational study on the utility of delta sequential organ failure assessment score in early prediction of clinical deterioration.
A retrospective study analysing predictive accuracy of modified early warning score for sepsis outcomes in medical intensive care.
A comparative study evaluating simplified acute physiology score versus quick sequential organ failure assessment for early risk stratification in septic patients.
A prospective study on daily organ dysfunction trends and their association with 14-day mortality in sepsis patients.
A randomised controlled trial assessing outcomes of protocol-based management guided by real-time scoring in septic shock.
A retrospective cohort study evaluating the accuracy of clinical judgement versus scoring systems in sepsis mortality prediction.
A comparative study on prognostic value of machine-learning assisted scoring models versus traditional scoring systems in sepsis.
A prospective study on the development and validation of an indigenous scoring tool for sepsis prognostication in resource-limited settings.
A prospective observational study evaluating 3-month functional outcomes in survivors of severe sepsis admitted to tertiary care ICUs.
A retrospective cohort study on readmission rates and predictors of poor outcomes among sepsis survivors discharged from critical care.
A comparative study of post-intensive care syndrome prevalence among sepsis versus non-sepsis survivors.
A prospective longitudinal study on quality of life at 6 months post-discharge in sepsis survivors and its association with initial organ dysfunction.
A randomised controlled trial on early physical rehabilitation in sepsis survivors and its impact on physical and cognitive outcomes.
A retrospective analysis of mortality and healthcare utilisation trends among sepsis survivors over one year following discharge.
A comparative study of neurocognitive outcomes in patients with sepsis-induced encephalopathy versus non-septic critically ill patients.
A prospective observational study assessing mental health status including anxiety and depression in sepsis survivors at 3 and 6 months.
A randomised controlled trial evaluating impact of structured post-ICU follow-up clinics on long-term functional recovery in sepsis survivors.
A comparative study assessing socioeconomic impact and return-to-work status in patients surviving sepsis versus those surviving trauma.
A prospective observational study assessing the awareness of sepsis recognition and management protocols among healthcare providers in Indian emergency departments.
A comparative study of outcomes before and after implementation of a sepsis care bundle in a tertiary care hospital ICU.
A randomised controlled trial on the effectiveness of mobile-based clinical decision support tools in early identification of sepsis in rural health centres.
A retrospective study on patterns of referral and delays in management of sepsis cases from peripheral hospitals to tertiary centres.
A comparative analysis of sepsis bundle compliance and mortality outcomes in public versus private healthcare settings in India.
A prospective study evaluating the effectiveness of infection control practices in preventing healthcare-associated sepsis in intensive care units.
A randomised controlled trial assessing the impact of continuous nursing education programs on early sepsis detection and response.
A retrospective study of trends in antibiotic resistance and their public health implications in sepsis-related bloodstream infections.
A prospective multicentric observational study on incidence, management practices, and outcomes of community-acquired sepsis in India.
A comparative study of sepsis awareness campaigns and their effectiveness in improving early hospital presentations in rural versus urban population.