CRITICAL CARE MEDICINE THESIS TOPICS FOR MD/DNB

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Choosing the right critical care medicine thesis topics is essential for building a strong academic and clinical foundation. With over 2000 critical care medicine thesis topics available, students can focus on a wide array of areas such as mechanical ventilation, septic shock management, neurocritical care, ICU infections, and trauma protocols. These diverse categories allow a focused approach in thesis writing. A well-researched and structured thesis in critical care medicine can be segmented into categories like pharmacological interventions, patient safety, diagnostic accuracy, and treatment outcomes. Selecting impactful critical care medicine thesis topics not only ensures academic success but also opens the door for publication in reputed medical journals — a critical requirement for teaching positions and promotions in medical colleges. Always choose your critical care medicine thesis topics wisely to ensure long-term professional benefits.

📌 Updated for 2025–2026 DM / DNB Critical Care Medicine Thesis Topics
This Critical Care Medicine thesis topics list is updated for the 2025–2026 academic cycle. These topics are curated based on recent DM/DNB submissions, ICU workload patterns in India, examiner expectations and current publication trends in critical care journals.
  • High-yield and clinically important ICU research areas
  • Feasible studies using routine MICU, SICU, NICU and emergency case load
  • Thesis topics with strong publication potential in critical care journals
🔥 Trending Research Areas in Critical Care Medicine for 2025–2026

Current Critical Care Medicine dissertations largely focus on sepsis, ventilator management, hemodynamic monitoring, acute organ failure and ICU mortality predictors. High-volume, examiner-friendly areas for the 2025–2026 academic year include:

  • Sepsis and septic shock: biomarkers, scoring systems and outcome predictors
  • Mechanical ventilation: weaning predictors, lung-protective strategies and ARDS outcomes
  • AKI in ICU: incidence, RRT indications, mortality and long-term outcomes
  • Shock resuscitation: lactate clearance, fluid responsiveness and vasopressor strategies
  1. A comparative study evaluating the diagnostic accuracy of procalcitonin versus C-reactive protein in early identification of sepsis in critically ill adult patients in Indian tertiary care hospitals.
  2. A randomised controlled trial to assess the impact of point-of-care lactate monitoring on early detection and outcome in suspected septic patients in emergency departments.
  3. A retrospective observational study on the role of neutrophil-to-lymphocyte ratio as a predictor of septic shock in intensive care unit admissions.
  4. A mixed-method prospective cohort study on serial procalcitonin levels and their association with mortality in patients with bloodstream infections.
  5. A comparative study of presepsin and interleukin-6 levels for early detection of bacterial sepsis in medical intensive care units.
  6. A randomised controlled trial on early use of sepsis alert algorithms based on lactate and vital signs in reducing time to antibiotic administration.
  7. A prospective observational study evaluating the diagnostic performance of soluble triggering receptor expressed on myeloid cells in differentiating sepsis from non-infective systemic inflammatory response syndrome.
  8. A comparative study between traditional clinical scoring systems and novel biomarkers in predicting septic shock in critically ill adults.
  9. A randomised controlled trial assessing the effectiveness of bedside sepsis screening tools in reducing diagnostic delay in rural hospital settings.
  10. A retrospective study correlating early biomarker trends with organ dysfunction progression in patients admitted with severe sepsis.
  11. A comparative study on outcomes of culture-guided versus empirical antibiotic therapy in patients with septic shock in intensive care units.
  12. A randomised controlled trial evaluating the efficacy of early de-escalation of antibiotics based on day 3 culture reports in patients with severe sepsis.
  13. A retrospective cohort study on the impact of multidrug-resistant organisms on mortality in septic patients admitted to tertiary care critical care units.
  14. A prospective observational study evaluating the clinical outcomes of using antibiotic stewardship protocols in management of sepsis.
  15. A comparative study of continuous infusion versus intermittent bolus of beta-lactam antibiotics in critically ill septic patients.
  16. A randomised controlled trial comparing combination antibiotic therapy versus monotherapy in management of ventilator-associated pneumonia-related sepsis.
  17. A retrospective analysis of inappropriate initial antibiotic use and its association with increased length of stay and mortality in septic patients.
  18. A mixed-method study assessing compliance with antimicrobial guidelines and its effect on sepsis-related mortality in public sector ICUs.
  19. A randomised controlled trial on the role of procalcitonin-guided discontinuation of antibiotics in critically ill patients with bacterial sepsis.
  20. A prospective study analysing delays in antibiotic administration and their association with clinical outcomes in emergency-diagnosed septic shock patients.
  21. A comparative study of lactate clearance versus central venous oxygen saturation as endpoints for resuscitation in septic shock.
  22. A randomised controlled trial comparing norepinephrine versus dopamine as first-line vasopressor in Indian patients with septic shock.
  23. A prospective observational study on the impact of early fluid resuscitation with balanced crystalloids versus normal saline on renal outcomes in septic patients.
  24. A retrospective cohort study evaluating the effect of time-to-fluid administration on mortality in septic shock.
  25. A randomised controlled trial comparing restrictive versus liberal fluid strategies in the management of sepsis-induced hypotension.
  26. A comparative study evaluating the use of passive leg raising test versus central venous pressure monitoring in guiding fluid therapy in septic shock.
  27. A prospective cohort study on vasopressor dependency index and its correlation with mortality in patients with septic shock.
  28. A randomised controlled trial comparing fixed-dose vasopressor escalation versus dynamic titration based on mean arterial pressure in septic patients.
  29. A retrospective analysis of vasopressor initiation timing and 28-day mortality in patients with septic shock.
  30. A comparative study on outcomes with early versus late initiation of vasopressin in patients with catecholamine-refractory septic shock.
  31. A randomised controlled trial evaluating early initiation versus delayed initiation of renal replacement therapy in septic acute kidney injury.
  32. A retrospective cohort study assessing the impact of sepsis-associated liver dysfunction on duration of organ support and mortality.
  33. A comparative study on high-flow nasal oxygen therapy versus non-invasive ventilation in sepsis-related acute hypoxemic respiratory failure.
  34. A prospective observational study of sepsis-induced coagulopathy and the utility of viscoelastic testing in guiding transfusion.
  35. A randomised controlled trial on the effect of low tidal volume ventilation strategy in septic patients with no acute respiratory distress syndrome.
  36. A comparative study of conventional mechanical ventilation versus airway pressure release ventilation in sepsis-induced lung injury.
  37. A retrospective study on the incidence of sepsis-related myocardial dysfunction and the need for inotropic support in ICU settings.
  38. A prospective cohort study correlating changes in hepatic enzymes and outcomes in sepsis-induced liver injury.
  39. A randomised controlled trial evaluating the impact of cytokine hemoadsorption therapy on vasopressor requirement in refractory septic shock.
  40. A mixed-method study exploring patterns of multi-organ dysfunction and prognostic indicators in sepsis patients requiring prolonged organ support.
  41. A comparative study of sepsis characteristics and outcomes in elderly versus younger adult patients admitted to intensive care units.
  42. A randomised controlled trial evaluating the role of early enteral nutrition in improving outcomes in septic patients with chronic liver disease.
  43. A prospective observational study on the clinical profile and outcomes of sepsis in patients with malignancy admitted to critical care units.
  44. A retrospective cohort study on maternal sepsis in Indian intensive care units: patterns, pathogens and mortality predictors.
  45. A comparative study of sepsis-related outcomes in diabetic versus non-diabetic critically ill patients.
  46. A prospective study assessing sepsis-related complications in patients on chronic dialysis admitted with bloodstream infections.
  47. A randomised controlled trial on early immunomodulator therapy in patients with septic shock and underlying autoimmune disorders.
  48. A retrospective analysis of the clinical course of patients with HIV-associated sepsis in tertiary care critical care units.
  49. A comparative study of septic shock outcomes in malnourished versus well-nourished patients admitted to intensive care.
  50. A prospective cohort study evaluating predictors of mortality in cirrhotic patients presenting with sepsis in emergency settings.
  51. A comparative study on outcomes of early versus delayed source control interventions in intra-abdominal sepsis in surgical intensive care units.
  52. A randomised controlled trial assessing the utility of bedside ultrasound versus clinical examination alone in detecting occult sources of sepsis.
  53. A prospective observational study evaluating the role of computed tomography imaging in identifying non-apparent sources of infection in sepsis patients.
  54. A retrospective analysis of percutaneous drainage versus surgical drainage for intra-abdominal abscesses in patients with sepsis.
  55. A randomised controlled trial comparing clinical outcomes of patients undergoing protocolised source identification versus standard care in undifferentiated sepsis.
  56. A comparative study on the effectiveness of prompt surgical source control versus medical management in sepsis from soft tissue infections.
  57. A prospective observational study on diagnostic yield of serial imaging for ongoing sepsis in patients with negative initial imaging.
  58. A retrospective cohort study on timing of invasive source control and its correlation with 28-day mortality in sepsis patients.
  59. A randomised controlled trial evaluating outcomes of early bronchoscopy-guided lavage in sepsis related to suspected lower respiratory infections.
  60. A comparative study of sepsis outcomes in patients with central line-associated bloodstream infection managed with early versus delayed catheter removal.
  61. A randomised controlled trial assessing the efficacy of low-dose corticosteroids in refractory septic shock in critically ill Indian patients.
  62. A comparative study evaluating the impact of immunonutrition versus standard nutrition on immune response markers in patients with sepsis.
  63. A prospective observational study on trends in immune cell profiles and their correlation with outcomes in septic patients.
  64. A retrospective cohort analysis of sepsis-associated immunosuppression and its link to secondary infections in intensive care units.
  65. A randomised controlled trial on intravenous immunoglobulin as adjunctive therapy in septic patients with multi-organ dysfunction.
  66. A comparative study of immune response and outcomes in sepsis caused by gram-positive versus gram-negative bacterial infections.
  67. A prospective study evaluating serum interleukin-10 and tumour necrosis factor-alpha levels as predictors of outcome in sepsis.
  68. A retrospective analysis of delayed mortality in sepsis survivors and its association with persistent immune dysfunction.
  69. A randomised controlled trial on immunomodulatory effect of selenium supplementation in patients with septic shock.
  70. A comparative study of corticosteroid responsiveness in sepsis patients with and without adrenal insufficiency.
  71. A comparative study of sequential organ failure assessment versus acute physiology and chronic health evaluation scoring systems in predicting mortality in sepsis.
  72. A randomised controlled trial evaluating clinical decision-making guided by dynamic scoring systems in the management of sepsis.
  73. A prospective observational study on the utility of delta sequential organ failure assessment score in early prediction of clinical deterioration.
  74. A retrospective study analysing predictive accuracy of modified early warning score for sepsis outcomes in medical intensive care.
  75. A comparative study evaluating simplified acute physiology score versus quick sequential organ failure assessment for early risk stratification in septic patients.
  76. A prospective study on daily organ dysfunction trends and their association with 14-day mortality in sepsis patients.
  77. A randomised controlled trial assessing outcomes of protocol-based management guided by real-time scoring in septic shock.
  78. A retrospective cohort study evaluating the accuracy of clinical judgement versus scoring systems in sepsis mortality prediction.
  79. A comparative study on prognostic value of machine-learning assisted scoring models versus traditional scoring systems in sepsis.
  80. A prospective study on the development and validation of an indigenous scoring tool for sepsis prognostication in resource-limited settings.
  81. A prospective observational study evaluating 3-month functional outcomes in survivors of severe sepsis admitted to tertiary care ICUs.
  82. A retrospective cohort study on readmission rates and predictors of poor outcomes among sepsis survivors discharged from critical care.
  83. A comparative study of post-intensive care syndrome prevalence among sepsis versus non-sepsis survivors.
  84. A prospective longitudinal study on quality of life at 6 months post-discharge in sepsis survivors and its association with initial organ dysfunction.
  85. A randomised controlled trial on early physical rehabilitation in sepsis survivors and its impact on physical and cognitive outcomes.
  86. A retrospective analysis of mortality and healthcare utilisation trends among sepsis survivors over one year following discharge.
  87. A comparative study of neurocognitive outcomes in patients with sepsis-induced encephalopathy versus non-septic critically ill patients.
  88. A prospective observational study assessing mental health status including anxiety and depression in sepsis survivors at 3 and 6 months.
  89. A randomised controlled trial evaluating impact of structured post-ICU follow-up clinics on long-term functional recovery in sepsis survivors.
  90. A comparative study assessing socioeconomic impact and return-to-work status in patients surviving sepsis versus those surviving trauma.
  91. A prospective observational study assessing the awareness of sepsis recognition and management protocols among healthcare providers in Indian emergency departments.
  92. A comparative study of outcomes before and after implementation of a sepsis care bundle in a tertiary care hospital ICU.
  93. A randomised controlled trial on the effectiveness of mobile-based clinical decision support tools in early identification of sepsis in rural health centres.
  94. A retrospective study on patterns of referral and delays in management of sepsis cases from peripheral hospitals to tertiary centres.
  95. A comparative analysis of sepsis bundle compliance and mortality outcomes in public versus private healthcare settings in India.
  96. A prospective study evaluating the effectiveness of infection control practices in preventing healthcare-associated sepsis in intensive care units.
  97. A randomised controlled trial assessing the impact of continuous nursing education programs on early sepsis detection and response.
  98. A retrospective study of trends in antibiotic resistance and their public health implications in sepsis-related bloodstream infections.
  99. A prospective multicentric observational study on incidence, management practices, and outcomes of community-acquired sepsis in India.
  100. A comparative study of sepsis awareness campaigns and their effectiveness in improving early hospital presentations in rural versus urban population.

Frequently Asked Questions – Critical Care Medicine Thesis Topics (2025–2026)

1. How do I choose a feasible Critical Care Medicine thesis topic for the 2025–2026 academic year?

Select a topic based on high-volume ICU conditions such as sepsis, ARDS, mechanical ventilation, AKI, shock, poisoning or post-operative ICU care. Ensure adequate case load, reliable investigations, and follow-up feasibility within your ICU structure. Avoid very rare ICU syndromes or technologies not consistently available in your centre.

2. Which study designs are commonly accepted for DM/DNB Critical Care Medicine theses?

Common study designs include prospective observational cohort studies, retrospective ICU data analyses, scoring system validations, diagnostic accuracy studies, biomarker evaluations, ventilator outcome research, and mortality predictor analyses. These designs are practical and widely accepted in Indian ICUs.

3. What should I discuss with my guide before finalising a Critical Care Medicine thesis topic?

Discuss expected ICU admissions for the condition, availability of biomarkers and ventilator data, scoring systems used in the ICU, feasibility of follow-up, data completeness in ICU records, ethical considerations and whether similar topics were recently approved. Choose a topic with strong outcome measures and predictable case flow.

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