Respiratory Medicine THESIS TOPICS FOR MD/DNB

Respiratory Medicine THESIS TOPICS FOR MD/DNB

respiratory medicine thesis topics

Below is the current list of 100 free respiratory medicine thesis topics for MD and DNB candidates. Each title uses a cross-sectional, observational, spirometric or clinicoradiological design that a postgraduate can complete from patients already attending the chest outpatient department, ward and pulmonary function laboratory, without prospective follow-up. Every topic on this list of pulmonary medicine thesis topics generates a complete respiratory medicine protocol and respiratory medicine synopsis in editable format. For more topics you can avail the service of premium Respiratory Medicine thesis topics.

Last reviewed and updated: August 2026

📌 Updated for 2026–2027 MD Respiratory Medicine admissions

This respiratory medicine thesis topic list is updated for the 2026–27 academic cycle. Topics are reviewed against recent dissertations, examiner preferences, feasibility in Indian medical colleges, and publication trends in pulmonary medicine.

  • Designs that avoid prospective follow-up and fit within postgraduate timelines
  • Topics achievable with spirometry, chest radiography, sputum examination and departmental imaging
  • Options with strong potential for publication
Generate a protocol from any topic below

Select Generate Protocol → beside any title and receive a submission-ready document built around that topic, containing all eighteen components:

  • Introduction / Synopsis
  • Research Question
  • Aim of the Study
  • Primary Objective
  • Secondary Objectives
  • Materials and Methods
  • Inclusion Criteria
  • Exclusion Criteria
  • Sample Size Calculation
  • Methodology
  • Statistical Analysis
  • Ethical Considerations
  • Review of Literature
  • References
  • Gantt Chart / Study Timeline
  • Patient Information Sheet
  • Consent Form
  • Data Collection Form

Tuberculosis Thesis Topics

  1. Clinical, Radiological and Microbiological Profile of Pulmonary Tuberculosis among Adults Attending a Tertiary Care Hospital: A Cross-Sectional Observational Study
  2. Association of Sputum Smear Grading with Radiological Extent of Disease in Patients with Pulmonary Tuberculosis: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical and Radiological Characteristics of Sputum Smear-Positive and Sputum Smear-Negative Pulmonary Tuberculosis: A Cross-Sectional Study
  4. Prevalence and Associated Factors of Diabetes Mellitus among Patients with Pulmonary Tuberculosis: A Cross-Sectional Study
  5. Comparative Assessment of Clinical and Radiological Characteristics of Pulmonary Tuberculosis in Patients with and without Diabetes Mellitus: A Cross-Sectional Study
  6. Association of Glycaemic Status with Radiological Severity of Pulmonary Tuberculosis among Patients with Diabetes Mellitus: A Cross-Sectional Analytical Study
  7. Clinical and Radiological Profile of Newly Diagnosed Extrapulmonary Tuberculosis among Adults: A Cross-Sectional Observational Study
  8. Prevalence and Pattern of Anaemia among Patients with Pulmonary Tuberculosis: A Cross-Sectional Study
  9. Association of Nutritional Status with Clinical and Radiological Severity of Pulmonary Tuberculosis: A Cross-Sectional Analytical Study
  10. Comparative Evaluation of Clinical Characteristics of Pulmonary Tuberculosis among Younger and Elderly Adults: A Cross-Sectional Study

Chronic Obstructive Pulmonary Disease

  1. Clinical, Radiological and Spirometric Profile of Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Observational Study
  2. Association of Smoking Exposure with Severity of Airflow Limitation in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical and Spirometric Characteristics of Smokers and Non-Smokers with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study
  4. Prevalence and Associated Factors of Pulmonary Hypertension among Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study
  5. Association of Body Mass Index with Severity of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analytical Study
  6. Comparative Assessment of Haematological Parameters in Patients with Mild-to-Moderate and Severe Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study
  7. Association of Peripheral Blood Eosinophil Count with Clinical Characteristics of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analytical Study
  8. Prevalence and Pattern of Cardiovascular Comorbidities among Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Observational Study
  9. Correlation of Six-Minute Walk Distance with Spirometric Severity in Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analytical Study
  10. Association of Chronic Obstructive Pulmonary Disease Severity with Health-Related Quality of Life: A Cross-Sectional Analytical Study

Bronchial Asthma

  1. Clinical and Spirometric Profile of Adult Patients with Bronchial Asthma Attending a Tertiary Care Hospital: A Cross-Sectional Observational Study
  2. Association of Body Mass Index with Asthma Control among Adult Patients with Bronchial Asthma: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical and Spirometric Characteristics of Controlled and Uncontrolled Bronchial Asthma: A Cross-Sectional Study
  4. Association of Peripheral Blood Eosinophil Count with Asthma Control and Spirometric Parameters: A Cross-Sectional Analytical Study
  5. Prevalence and Pattern of Allergic Comorbidities among Adult Patients with Bronchial Asthma: A Cross-Sectional Observational Study
  6. Comparative Assessment of Asthma Control among Patients with and without Allergic Rhinitis: A Cross-Sectional Study
  7. Association of Inhaler Technique with Asthma Control among Patients Receiving Inhaled Therapy: A Cross-Sectional Analytical Study
  8. Assessment of Knowledge and Practices Regarding Inhaler Use among Patients with Bronchial Asthma: A Cross-Sectional Study
  9. Comparative Evaluation of Inhaler Technique among Patients Using Different Inhaler Devices for Bronchial Asthma: A Cross-Sectional Study
  10. Association of Asthma Control with Health-Related Quality of Life among Adult Patients: A Cross-Sectional Analytical Study

Interstitial Lung Diseases

  1. Clinical, Radiological and Spirometric Profile of Patients with Interstitial Lung Disease: A Cross-Sectional Observational Study
  2. Distribution of High-Resolution Computed Tomography Patterns among Patients with Interstitial Lung Disease: A Cross-Sectional Study
  3. Association of High-Resolution Computed Tomography Extent of Disease with Pulmonary Function Parameters in Interstitial Lung Disease: A Cross-Sectional Analytical Study
  4. Comparative Evaluation of Clinical and Radiological Characteristics of Idiopathic and Connective Tissue Disease-Associated Interstitial Lung Disease: A Cross-Sectional Study
  5. Prevalence and Pattern of Pulmonary Hypertension among Patients with Interstitial Lung Disease: A Cross-Sectional Study
  6. Association of Oxygen Saturation with High-Resolution Computed Tomography Severity among Patients with Interstitial Lung Disease: A Cross-Sectional Analytical Study
  7. Comparative Assessment of Spirometric Parameters among Different High-Resolution Computed Tomography Patterns of Interstitial Lung Disease: A Cross-Sectional Study
  8. Clinical and Radiological Profile of Connective Tissue Disease-Associated Interstitial Lung Disease: A Cross-Sectional Observational Study
  9. Correlation of Six-Minute Walk Distance with Pulmonary Function Parameters in Patients with Interstitial Lung Disease: A Cross-Sectional Analytical Study
  10. Association of Radiological Severity with Health-Related Quality of Life among Patients with Interstitial Lung Disease: A Cross-Sectional Analytical Study

Pleural Diseases and Pleural Effusion

  1. Clinical, Radiological and Biochemical Profile of Patients with Pleural Effusion: A Cross-Sectional Observational Study
  2. Comparative Evaluation of Clinical and Pleural Fluid Characteristics of Tuberculous and Malignant Pleural Effusions: A Cross-Sectional Study
  3. Association of Pleural Fluid Adenosine Deaminase Levels with Clinical Characteristics of Tuberculous Pleural Effusion: A Cross-Sectional Analytical Study
  4. Comparative Evaluation of Pleural Fluid Biochemical Parameters in Transudative and Exudative Pleural Effusions: A Cross-Sectional Study
  5. Aetiological Spectrum of Exudative Pleural Effusion among Adults Presenting to a Tertiary Care Hospital: A Cross-Sectional Observational Study
  6. Correlation of Ultrasonographic Characteristics with Pleural Fluid Analysis in Patients with Pleural Effusion: A Cross-Sectional Analytical Study
  7. Comparative Evaluation of Ultrasonography and Chest Radiography for Characterisation of Pleural Effusion: A Cross-Sectional Study
  8. Clinical and Microbiological Profile of Patients with Empyema Thoracis: A Cross-Sectional Observational Study
  9. Comparative Evaluation of Pleural Fluid Characteristics in Parapneumonic and Tuberculous Pleural Effusions: A Cross-Sectional Study
  10. Association of Pleural Fluid Cytological Findings with Radiological Characteristics in Suspected Malignant Pleural Effusion: A Cross-Sectional Analytical Study

Pneumonia and Lower Respiratory Tract Infections

  1. Clinical, Radiological and Microbiological Profile of Community-Acquired Pneumonia among Adults: A Cross-Sectional Observational Study
  2. Association of Clinical Severity Scores with Radiological Extent of Community-Acquired Pneumonia: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical Characteristics of Community-Acquired Pneumonia among Younger and Elderly Adults: A Cross-Sectional Study
  4. Prevalence and Pattern of Comorbidities among Adults Presenting with Community-Acquired Pneumonia: A Cross-Sectional Observational Study
  5. Association of Neutrophil-to-Lymphocyte Ratio with Severity of Community-Acquired Pneumonia: A Cross-Sectional Analytical Study
  6. Comparative Evaluation of Clinical and Laboratory Parameters in Bacterial and Viral Lower Respiratory Tract Infections: A Cross-Sectional Study
  7. Microbiological Profile and Antimicrobial Susceptibility Pattern of Bacterial Isolates from Patients with Lower Respiratory Tract Infection: A Cross-Sectional Study
  8. Clinical and Microbiological Profile of Lower Respiratory Tract Infections among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Observational Study
  9. Comparative Assessment of Community-Acquired Pneumonia in Patients with and without Type 2 Diabetes Mellitus: A Cross-Sectional Study
  10. Association of Serum Albumin and Nutritional Status with Severity of Community-Acquired Pneumonia: A Cross-Sectional Analytical Study

Bronchiectasis and Chronic Suppurative Lung Diseases

  1. Clinical, Radiological and Microbiological Profile of Patients with Bronchiectasis: A Cross-Sectional Observational Study
  2. Association of High-Resolution Computed Tomography Extent of Bronchiectasis with Spirometric Abnormalities: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical Characteristics of Post-Tubercular and Non-Tubercular Bronchiectasis: A Cross-Sectional Study
  4. Microbiological Profile of Sputum Isolates among Patients with Bronchiectasis: A Cross-Sectional Observational Study
  5. Association of Sputum Microbiology with Radiological Severity of Bronchiectasis: A Cross-Sectional Analytical Study
  6. Comparative Evaluation of Spirometric Patterns in Patients with Localised and Diffuse Bronchiectasis: A Cross-Sectional Study
  7. Prevalence and Pattern of Haemoptysis among Patients with Bronchiectasis: A Cross-Sectional Study
  8. Association of Nutritional Status with Clinical Severity of Bronchiectasis: A Cross-Sectional Analytical Study
  9. Comparative Assessment of Quality of Life among Patients with Post-Tubercular and Other Forms of Bronchiectasis: A Cross-Sectional Study
  10. Clinical and Radiological Profile of Patients with Post-Tubercular Structural Lung Disease: A Cross-Sectional Observational Study

Lung Cancer and Pulmonary Nodules

  1. Clinical, Radiological and Histopathological Profile of Primary Lung Cancer among Patients Presenting to a Tertiary Care Hospital: A Cross-Sectional Observational Study
  2. Association of Smoking Exposure with Histological Type of Lung Cancer: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Clinical and Radiological Characteristics of Lung Cancer in Smokers and Non-Smokers: A Cross-Sectional Study
  4. Distribution of Histopathological Types of Lung Cancer according to Age, Sex and Smoking Status: A Cross-Sectional Observational Study
  5. Association of Radiological Tumour Characteristics with Histopathological Type of Lung Cancer: A Cross-Sectional Analytical Study
  6. Comparative Evaluation of Clinical Presentation of Small-Cell and Non-Small-Cell Lung Carcinoma: A Cross-Sectional Study
  7. Clinical and Radiological Profile of Lung Cancer among Non-Smoking Patients: A Cross-Sectional Observational Study
  8. Association of Performance Status with Clinical Stage at Presentation among Patients with Lung Cancer: A Cross-Sectional Analytical Study
  9. Comparative Evaluation of Computed Tomography Characteristics of Benign and Malignant Solitary Pulmonary Nodules: A Cross-Sectional Study
  10. Pattern of Metastatic Disease at Initial Presentation among Patients with Primary Lung Cancer: A Cross-Sectional Observational Study

Sleep-Related Breathing Disorders and Obesity

  1. Prevalence and Associated Risk Factors of High Risk for Obstructive Sleep Apnoea among Adults Attending a Tertiary Care Hospital: A Cross-Sectional Study
  2. Association of Body Mass Index and Neck Circumference with Risk of Obstructive Sleep Apnoea: A Cross-Sectional Analytical Study
  3. Comparative Assessment of Obstructive Sleep Apnoea Risk among Obese and Non-Obese Adults: A Cross-Sectional Study
  4. Association of Obstructive Sleep Apnoea Risk with Hypertension among Adult Patients: A Cross-Sectional Analytical Study
  5. Prevalence of Excessive Daytime Sleepiness among Patients at High Risk for Obstructive Sleep Apnoea: A Cross-Sectional Study
  6. Comparative Assessment of Sleep Quality among Patients with and without High Risk for Obstructive Sleep Apnoea: A Cross-Sectional Study
  7. Association of Waist Circumference and Waist-to-Hip Ratio with Obstructive Sleep Apnoea Risk among Adults: A Cross-Sectional Analytical Study
  8. Prevalence of High Risk for Obstructive Sleep Apnoea among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study
  9. Comparative Evaluation of Cardiometabolic Risk Factors among Adults with Low and High Risk for Obstructive Sleep Apnoea: A Cross-Sectional Study
  10. Association of Obstructive Sleep Apnoea Risk with Health-Related Quality of Life among Obese Adults: A Cross-Sectional Analytical Study

Pulmonary Function, Smoking and Occupational Lung Diseases

  1. Spirometric Profile of Chronic Smokers Attending a Respiratory Medicine Department: A Cross-Sectional Observational Study
  2. Association of Smoking Index with Spirometric Abnormalities among Adult Smokers: A Cross-Sectional Analytical Study
  3. Comparative Evaluation of Pulmonary Function Parameters among Smokers, Former Smokers and Never-Smokers: A Cross-Sectional Study
  4. Prevalence of Respiratory Symptoms and Spirometric Abnormalities among Workers Exposed to Occupational Dust: A Cross-Sectional Study
  5. Association of Duration of Occupational Dust Exposure with Pulmonary Function Parameters among Industrial Workers: A Cross-Sectional Analytical Study
  6. Comparative Assessment of Respiratory Symptoms and Spirometric Parameters among Dust-Exposed and Non-Exposed Workers: A Cross-Sectional Study
  7. Clinical, Radiological and Spirometric Profile of Patients with Occupational Lung Diseases: A Cross-Sectional Observational Study
  8. Association of Biomass Fuel Exposure with Chronic Respiratory Symptoms and Spirometric Abnormalities among Adult Women: A Cross-Sectional Analytical Study
  9. Comparative Evaluation of Pulmonary Function Parameters among Biomass Fuel-Exposed and Non-Exposed Adult Women: A Cross-Sectional Study
  10. Prevalence and Associated Factors of Abnormal Spirometry among Adults with Chronic Respiratory Symptoms Attending a Tertiary Care Hospital: A Cross-Sectional Study

Subscribing to the premium thesis topics not only lets you browse the full premium list, it also gives you online guidance (guidance doesnt mean complete protocol) on synopsis writing, sample size calculation, inclusion and exclusion criteria, and support throughout thesis writing. If you do not subscribe, please still feel free to contact me for guidance.

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Studying outside India?

The topics above work as research questions anywhere — what changes is the document your institution expects. Two different routes, depending on which applies to you.

Board residents — SCFHS, Arab Board, OMSB, KIMS, QCHP, NHRA, DHA and DOH

Pulmonary medicine residency across the Gulf carries a mandatory research requirement, and the equivalent of an Indian synopsis is the research proposal submitted to your IRB before a research project begins. The format differs from the Indian one: it additionally requires a Gantt chart, a budget and resources section, and a Declaration of Helsinki statement.

Generate a residency research proposal →

PhD and Master's candidates — Saudi Arabia, Malaysia, the Gulf and beyond

University graduate programmes generally require a full research proposal of roughly 6,000 to 10,000 words, with an extended literature review, a theoretical framework and a detailed methodology chapter — considerably longer and deeper than a residency proposal. These are written individually, by a medical doctor, with no artificial intelligence generation and no plagiarism, and revised until your supervisor accepts them.

Enquire about a PhD research proposal →

🔥 Trending research areas in Respiratory Medicine for 2026–27

Based on recent thesis submissions and examiner preferences in MD Respiratory Medicine departments across India, these are the emerging high-interest areas:

  • Tuberculosis and diabetes comorbidity and its effect on clinical and radiological severity
  • Post-tubercular structural lung disease as a distinct chronic respiratory burden
  • Peripheral blood eosinophil count as a phenotyping marker in asthma and chronic obstructive pulmonary disease
  • Biomass fuel and occupational dust exposure as determinants of airflow limitation

Protocol and synopsis guidance

What a respiratory medicine protocol must contain

A respiratory medicine protocol is judged on internal consistency: the research question, objectives, methodology and statistical plan must all describe the same study. The primary objective should be a single measurable endpoint — one association, one comparison, one profile — with everything else demoted to secondary objectives.

Spirometry needs a paragraph of its own, and it is where these protocols are most often found wanting. State the spirometer make and model, its calibration schedule, that testing follows the current international standardisation criteria for acceptability and repeatability, how many manoeuvres are performed and which values are reported. State whether spirometry is pre-bronchodilator or post-bronchodilator, and with which bronchodilator, dose and waiting interval — this matters because chronic obstructive pulmonary disease cannot be diagnosed on pre-bronchodilator values, so a study defining the disease that way is defining something else. Name the reference equation used to derive predicted values and say why, since equations derived in other populations systematically misclassify Indian subjects. Say who performs the test and what training they have had.

Name every classification and instrument with its version: the current GOLD assessment for chronic obstructive pulmonary disease, the GINA framework and the asthma control instrument you are applying, the multidisciplinary criteria and pattern definitions used for interstitial lung disease, Light's criteria with the adenosine deaminase cut-off and its source for pleural fluid, the severity score used for community-acquired pneumonia, the histological classification and staging edition for lung cancer, and the named questionnaire used to stratify obstructive sleep apnoea risk. Where quality of life is measured, name the instrument, confirm a validated translation is used, and check whether a licence is required.

Define exposure numerically. Smoking must be quantified as pack-years or a stated smoking index with the formula given, not recorded as smoker or non-smoker alone, and former smokers need a defined interval since cessation. Biomass and occupational dust exposure need a stated duration and intensity measure. The six-minute walk test needs the corridor length, the standardised encouragement and the stopping criteria stated. Inclusion and exclusion criteria are written for patients and must address current treatment, recent exacerbation and any condition that prevents valid spirometry.

Respiratory medicine synopsis versus protocol

A respiratory medicine synopsis is the condensed document of two to four pages — title, introduction, aim and objectives, brief methodology, sample size and references — submitted for registration of the dissertation topic. The respiratory medicine protocol is the expanded version of twelve to twenty pages carrying the full review of literature, detailed methodology including spirometric technique and reference equations, classification systems and exposure definitions, statistical plan, study timeline and annexures including the patient information sheet, consent form, data collection proforma and a copy of any control or quality-of-life instrument used.

In practice the synopsis is extracted from the protocol rather than written separately, which is faster and produces a more coherent document. Check your university's prescribed proforma before submission, since rejections on formatting grounds are common and entirely avoidable.

Sample size and statistical analysis

Prevalence studies — diabetes among tuberculosis patients, pulmonary hypertension in chronic obstructive pulmonary disease, anaemia, obstructive sleep apnoea risk — use a proportion-based calculation from a comparable published study, with the desired absolute precision and confidence level, citing the source. Comparative studies of a spirometric or laboratory parameter use the difference in means with the standard deviation from prior literature. Correlation studies, of which this list has many, use the expected correlation coefficient. Where a marker is evaluated against a diagnostic reference — adenosine deaminase against a final diagnosis of tuberculous effusion, computed tomography features against histopathology in pulmonary nodules — the calculation must rest on expected sensitivity or specificity together with the expected prevalence.

Name the tests rather than promising that data will be analysed. Comparison between two groups uses the independent t-test or the Mann-Whitney U test with a stated normality test; comparison across severity grades calls for analysis of variance or the Kruskal-Wallis test with a post-hoc comparison; proportions use the chi-squared test with Fisher's exact test for small cells. Correlation between a radiological score and a spirometric value uses the Pearson or Spearman coefficient, with Spearman preferred where one variable is an ordered grade. Where a cut-off is derived, receiver operating characteristic analysis with area under the curve is expected, and where two observers score radiographs or computed tomography extent, report interobserver agreement as a kappa statistic and state that the reader is blinded to the clinical and functional data.

Frequently Asked Questions – Respiratory Medicine Thesis Topics (2026–27)

1. How do I choose a feasible respiratory medicine thesis topic for the 2026–27 academic year?

Start with your outpatient and admission registers. Tuberculosis, chronic obstructive pulmonary disease, asthma, pleural effusion and community-acquired pneumonia accrue readily in almost every department. Interstitial lung disease, empyema and lung cancer present far less often, and a study needing sixty such patients may not accrue within two years.

Then check the pulmonary function laboratory. A large share of the topics above depend on spirometry, and whether the machine is calibrated, whether a trained technician is available, and how many patients a day can be tested alongside clinical work will decide your pace more than referral numbers do. Finally, confirm the gap: clinicoradiological profile studies of tuberculosis and chronic obstructive pulmonary disease are heavily published in India, so your question needs a comparison, marker or exposure that comparable centres have not already reported.

2. Which study designs are commonly accepted for MD Respiratory Medicine theses?

Cross-sectional observational and analytical designs account for the large majority of accepted dissertations. Clinical, radiological and spirometric profile studies of a defined condition, prevalence studies of a comorbidity within a disease group, association studies between a marker or exposure and disease severity, and comparative designs contrasting two patient groups are all well established.

Diagnostic comparisons — pleural fluid parameters against a final diagnosis, imaging against histopathology — form a further stream. Randomised trials of a drug or device require trial registration and closer scrutiny, and follow-up designs risk incomplete data once patients stop attending, which is common in chronic respiratory disease.

3. What should I discuss with my guide before finalising a Respiratory Medicine thesis topic?

Bring three to five shortlisted titles rather than one, since guides frequently rule out a topic on grounds you could not have known — an ongoing departmental study, a spirometer awaiting servicing, a referral stream that has changed.

Settle four things in that meeting: annual case volume for your condition, pulmonary function laboratory access and who performs the tests, what imaging or laboratory support is needed beyond routine and who funds it, and which journal the eventual paper is aimed at.

4. Can a respiratory medicine thesis be completed without high-resolution computed tomography or advanced testing?

Yes. Chest radiography, sputum examination, spirometry, pulse oximetry, the six-minute walk test, pleural fluid analysis and validated questionnaires support a large share of the topics above. The sleep-related group is designed on exactly this principle: it studies risk stratified by questionnaire rather than by polysomnography, which most departments do not have. That is a legitimate design provided the objectives and the title say risk of obstructive sleep apnoea rather than obstructive sleep apnoea, since a questionnaire identifies people at high risk and does not diagnose the condition. Keep that distinction in every sentence of the protocol, because losing it is the fastest way to have this group of topics criticised.

5. What is the difference between a respiratory medicine synopsis and a protocol?

The synopsis is the condensed two to four page document submitted for topic registration. The protocol is the full document of twelve to twenty pages containing the detailed review of literature, methodology with spirometric technique, reference equations, classification systems and exposure definitions, statistical plan, timeline and annexures. The synopsis is normally extracted from the completed protocol.

6. What ethical considerations apply to tuberculosis and respiratory research?

Full institutional ethics committee approval before data collection, with written informed consent from every patient. Three points need explicit attention in this speciality.

Infection control. Studies collecting sputum must state where specimens are produced — a designated well-ventilated area or booth, never an enclosed room or corridor — what respiratory protection the investigator uses, and how specimens are transported. Committees expect this in any tuberculosis protocol and its absence is noticeable.

Notification and confidentiality. State that any patient newly diagnosed during the study is notified and linked to treatment under the national programme as usual, that the study does not delay or substitute for routine care, and that tuberculosis and human immunodeficiency virus status are handled with particular confidentiality, with no identifying detail in the dissertation.

Procedures and exposure. Where spirometry, the six-minute walk test or a bronchodilator challenge is performed for research, say so and state the supervision and stopping criteria. Where imaging is performed for the study rather than clinically indicated, address the radiation exposure directly, since committees will ask whether the scan would have been done anyway. Occupational and biomass studies additionally need permission from the employer or the community, which takes time and runs alongside ethics clearance.

7. What spirometry details must the protocol specify?

The spirometer make, model and calibration schedule; that testing follows current international standardisation criteria for acceptability and repeatability; the number of manoeuvres and which values are reported; whether values are pre-bronchodilator or post-bronchodilator, with the bronchodilator, dose and waiting interval; the reference equation used for predicted values, with justification; and who performs the test and their training. Two of these decide whether the study means anything. Chronic obstructive pulmonary disease requires post-bronchodilator confirmation of persistent airflow limitation, so a protocol that classifies severity on pre-bronchodilator values is not studying the disease it names. And predicted values derived from populations with different anthropometry will systematically misclassify Indian patients as normal or abnormal, so the choice of reference equation must be stated and defended rather than left to whatever the machine defaults to.

8. Is a PhD research proposal different from an MD synopsis?

Substantially. A PhD proposal typically runs 6,000 to 10,000 words and carries an extended critical literature review, a theoretical framework, a detailed methodology chapter and a discussion of expected contribution to the field. An MD synopsis is a two to four page registration document. The research question can be the same; the depth expected is not.

9. When should I register my respiratory medicine thesis topic?

Most universities require registration within six to nine months of joining. Shortlist in the first two months, finalise with your guide by the third, and file for ethics clearance immediately afterwards. Where microbiology, pathology or radiology must supply part of your data, secure that cooperation in writing at the same time, and where an industrial workplace or community is involved, begin seeking permission then rather than after approval.

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