1.    First and Foremost is your interest. If you have keen interest in some topic then you should go for it. For example some people are interested in imaging techniques so even if you are doin PG in pediatrics he or she can choose neuroimaging in children with seizures or delayed developmental milestones etc.

      2.    You should have enough numbers of patients to undertake a research project. Like if you make a rare disease an inclusion criterion then you may not get enough patients.

      3.    The facilities required to undertake a particular study should be present in your institute so           that patients wont have to bear the cost of your research and the tests can be done free within the institute.

       4.    You should always bear in mind the objective of the study. The problem statement must be   clear in your mind so that at the end of the study you have an answer to the problem statement.

       5.    Always give due importance to the interest of your PG teacher. Usually PG teachers are alotted   before thesis topic selection and you may get 1-2 months to understand the interest of your PG   teacher. Some PG teacher have special interest in a particular disease and if you align your thesis   with his or her interest then that is a good strategy.


        Hope that answers the question     .

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There are many methods of sample size determination. It is one of the first hurdle when someone starts writing a thesis. I have tried to give simplest way of determination of sample size. You need to show the method to your PG teacher before you include this method in your thesis. First confirm from your PG teacher and then only proceed.

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