These neurodegenerative diseases thesis topics are designed for MD Medicine and DNB Medicine candidates studying Parkinson disease, dementias, motor neuron disease, atypical parkinsonism, hereditary choreiform disorders, degenerative ataxias and related syndromes. The emphasis is on clinically feasible work that can be completed within one thesis period using patients, neurological examination, cognitive and functional scales, routine laboratory tests, neuroimaging and other investigations already available during standard care. Strong projects define the neurodegenerative phenotype carefully, use validated instruments and separate disease severity from age, education, frailty and comorbidity. The same framework can be adapted for neurodegenerative disease research topics, an MD Medicine neurodegenerative diseases protocol or a DNB Medicine neurodegenerative diseases synopsis before final discussion with the postgraduate guide.
Last reviewed and updated: September 2026 · 2026–27 admissions
Our MD Medicine Thesis Guidance provides structured protocols, sample size formulas, and institutional review board (IRB) layout guides.
Parkinson Disease
Clinical profile and spectrum of motor and non-motor manifestations among adults with Parkinson disease attending a tertiary care hospital: a cross-sectional observational study
Association of age and duration of illness with motor severity among adults with Parkinson disease: a cross-sectional analytical study
Relationship between tremor severity and functional disability among patients with Parkinson disease: a cross-sectional observational study
Comparison of clinical characteristics of tremor-dominant and akinetic-rigid phenotypes of Parkinson disease: a comparative cross-sectional study
Association of body mass index with motor severity among adults with Parkinson disease: a cross-sectional analytical study
Prevalence of undernutrition among adults with Parkinson disease and its association with functional disability: a cross-sectional study
Association of mid-upper arm circumference with functional status among patients with Parkinson disease: a cross-sectional analytical study
Comparison of nutritional status between patients with mild and advanced Parkinson disease: a comparative cross-sectional study
Prevalence of anaemia among adults with Parkinson disease and its association with functional impairment: a cross-sectional observational study
Association of haemoglobin concentration with mobility limitation among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of vitamin B12 deficiency among adults with Parkinson disease and its association with neurological disability: a cross-sectional study
Comparison of vitamin B12 status between patients with Parkinson disease with and without cognitive impairment: a comparative cross-sectional study
Association of serum vitamin D concentration with postural instability among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of vitamin D deficiency among adults with Parkinson disease and its association with fall risk: a cross-sectional study
Association of serum uric acid with motor severity among adults with Parkinson disease: a cross-sectional observational study
Relationship between serum albumin and functional status among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of orthostatic hypotension among adults with Parkinson disease: a cross-sectional observational study
Association of orthostatic hypotension with disease severity among patients with Parkinson disease: a cross-sectional analytical study
Comparison of clinical characteristics of Parkinson disease patients with and without orthostatic hypotension: a comparative cross-sectional study
Prevalence of constipation among adults with Parkinson disease and its association with disease severity: a cross-sectional study
Association of constipation severity with autonomic dysfunction among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of urinary symptoms among patients with Parkinson disease and their association with functional disability: a cross-sectional observational study
Comparison of autonomic symptom burden between men and women with Parkinson disease: a comparative cross-sectional study
Prevalence of excessive daytime sleepiness among adults with Parkinson disease: a cross-sectional study
Association of excessive daytime sleepiness with motor severity among patients with Parkinson disease: a cross-sectional analytical study
Relationship between sleep quality and functional disability among adults with Parkinson disease: a cross-sectional observational study
Comparison of sleep quality between patients with early-stage and advanced Parkinson disease: a comparative cross-sectional study
Prevalence of rapid eye movement sleep behaviour disorder symptoms among adults with Parkinson disease: a cross-sectional study
Association of probable rapid eye movement sleep behaviour disorder with cognitive impairment in Parkinson disease: a cross-sectional analytical study
Prevalence of depressive symptoms among adults with Parkinson disease and their association with motor disability: a cross-sectional study
Association of depressive symptom severity with quality of life among patients with Parkinson disease: a cross-sectional analytical study
Comparison of motor and non-motor symptom burden among Parkinson disease patients with and without depressive symptoms: a comparative cross-sectional study
Prevalence of anxiety symptoms among adults with Parkinson disease: a cross-sectional observational study
Association of anxiety symptoms with tremor severity among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of cognitive impairment among adults with Parkinson disease attending a tertiary care hospital: a cross-sectional study
Association of age, education, and disease severity with cognitive impairment among patients with Parkinson disease: a cross-sectional analytical study
Comparison of clinical characteristics of Parkinson disease patients with and without cognitive impairment: a comparative cross-sectional study
Relationship between executive dysfunction and motor severity among patients with Parkinson disease: a cross-sectional observational study
Association of gait impairment with cognitive dysfunction among adults with Parkinson disease: a cross-sectional analytical study
Prevalence of falls among adults with Parkinson disease and their associated clinical factors: a cross-sectional study
Association of postural instability with fall risk among adults with Parkinson disease: a cross-sectional analytical study
Comparison of clinical characteristics of Parkinson disease patients with and without recurrent falls: a comparative cross-sectional study
Association of freezing of gait with disease severity among adults with Parkinson disease: a cross-sectional observational study
Relationship between lower limb muscle strength and mobility limitation in Parkinson disease: a cross-sectional analytical study
Comparison of functional mobility between tremor-dominant and postural-instability-dominant Parkinson disease: a comparative cross-sectional study
Prevalence of dysphagia symptoms among adults with Parkinson disease: a cross-sectional observational study
Association of dysphagia with nutritional status among adults with Parkinson disease: a cross-sectional analytical study
Comparison of nutritional parameters between Parkinson disease patients with and without swallowing difficulty: a comparative cross-sectional study
Prevalence of drooling among patients with Parkinson disease and its association with disease severity: a cross-sectional study
Association of speech impairment with functional disability among adults with Parkinson disease: a cross-sectional analytical study
Prevalence of olfactory dysfunction among adults with Parkinson disease and its association with non-motor symptom burden: a cross-sectional observational study
Association of impaired smell perception with cognitive impairment among patients with Parkinson disease: a cross-sectional analytical study
Prevalence of metabolic syndrome among adults with Parkinson disease: a cross-sectional study
Comparison of metabolic risk factors between Parkinson disease patients and age-matched adults without neurodegenerative disease: a comparative cross-sectional study
Association of diabetes mellitus with motor severity among adults with Parkinson disease: a cross-sectional analytical study
Comparison of clinical characteristics of Parkinson disease patients with and without diabetes mellitus: a comparative cross-sectional study
Association of hypertension with cognitive impairment among older adults with Parkinson disease: a cross-sectional analytical study
Prevalence of electrocardiographic abnormalities among adults with Parkinson disease and autonomic symptoms: a cross-sectional observational study
Association of polypharmacy with orthostatic symptoms and falls among older adults with Parkinson disease: a cross-sectional analytical study
Comparison of motor severity, cognitive impairment, autonomic symptoms, and nutritional status across different clinical stages of Parkinson disease: a comparative cross-sectional study
Alzheimer Disease and Other Common Dementias
Clinical and cognitive profile of older adults with Alzheimer disease attending a tertiary care hospital: a cross-sectional observational study
Association of age and educational status with cognitive severity among patients with Alzheimer disease: a cross-sectional analytical study
Relationship between duration of cognitive symptoms and severity of functional dependence among adults with Alzheimer disease: a cross-sectional observational study
Comparison of cognitive and functional characteristics of early-onset and late-onset Alzheimer disease: a comparative cross-sectional study
Prevalence of behavioural and psychological symptoms among adults with Alzheimer disease: a cross-sectional study
Association of behavioural symptom burden with severity of cognitive impairment among patients with Alzheimer disease: a cross-sectional analytical study
Comparison of cognitive characteristics of patients with Alzheimer disease with and without prominent behavioural symptoms: a comparative cross-sectional study
Prevalence of depressive symptoms among adults with Alzheimer disease and their association with cognitive severity: a cross-sectional study
Association of anxiety symptoms with functional dependence among patients with Alzheimer disease: a cross-sectional analytical study
Prevalence of sleep disturbance among adults with Alzheimer disease: a cross-sectional observational study
Association of poor sleep quality with cognitive impairment among patients with Alzheimer disease: a cross-sectional analytical study
Comparison of cognitive performance among Alzheimer disease patients with and without significant sleep disturbance: a comparative cross-sectional study
Prevalence of nutritional impairment among older adults with Alzheimer disease: a cross-sectional study
Association of body mass index with cognitive and functional severity among patients with Alzheimer disease: a cross-sectional analytical study
Relationship between serum albumin and functional dependence among older adults with Alzheimer disease: a cross-sectional observational study
Comparison of nutritional status between patients with mild and moderate-to-severe Alzheimer disease: a comparative cross-sectional study
Prevalence of anaemia among adults with Alzheimer disease and its association with cognitive severity: a cross-sectional study
Association of haemoglobin concentration with cognitive performance among patients with Alzheimer disease: a cross-sectional analytical study
Prevalence of vitamin B12 deficiency among older adults with dementia: a cross-sectional observational study
Association of vitamin B12 status with cognitive impairment among adults with Alzheimer disease: a cross-sectional analytical study
Comparison of cognitive performance between Alzheimer disease patients with normal and low vitamin B12 levels: a comparative cross-sectional study
Prevalence of vitamin D deficiency among older adults with Alzheimer disease: a cross-sectional study
Association of serum vitamin D levels with cognitive and functional impairment among patients with Alzheimer disease: a cross-sectional analytical study
Prevalence of thyroid dysfunction among adults presenting with dementia syndrome: a cross-sectional observational study
Association of thyroid-stimulating hormone concentration with cognitive performance among older adults with dementia: a cross-sectional analytical study
Comparison of metabolic abnormalities between older adults with dementia and cognitively normal older adults: a comparative cross-sectional study
Prevalence of diabetes mellitus among adults with Alzheimer disease and its association with cognitive severity: a cross-sectional study
Association of glycaemic control with cognitive performance among patients with Alzheimer disease and diabetes mellitus: a cross-sectional analytical study
Comparison of cognitive and functional characteristics of Alzheimer disease patients with and without diabetes mellitus: a comparative cross-sectional study
Association of hypertension with cognitive impairment among older adults with Alzheimer disease: a cross-sectional analytical study
Prevalence of dyslipidaemia among adults with Alzheimer disease and its association with cognitive severity: a cross-sectional study
Association of metabolic syndrome with cognitive and functional impairment among older adults with dementia: a cross-sectional analytical study
Comparison of cardiovascular risk-factor burden between patients with Alzheimer disease and cognitively normal older adults: a comparative cross-sectional study
Prevalence of orthostatic hypotension among older adults with dementia: a cross-sectional observational study
Association of orthostatic hypotension with falls among older adults with dementia: a cross-sectional analytical study
Prevalence of falls among older adults with Alzheimer disease and their associated clinical factors: a cross-sectional study
Comparison of cognitive and functional characteristics of dementia patients with and without recurrent falls: a comparative cross-sectional study
Association of gait speed with cognitive impairment among older adults with Alzheimer disease: a cross-sectional analytical study
Relationship between handgrip strength and functional dependence among older adults with dementia: a cross-sectional observational study
Prevalence of sarcopenia among older adults with Alzheimer disease and its association with functional impairment: a cross-sectional study
Association of frailty with cognitive severity among older adults with dementia: a cross-sectional analytical study
Comparison of nutritional status, frailty, and functional dependence among patients with mild and advanced dementia: a comparative cross-sectional study
Prevalence of urinary incontinence among older adults with dementia and its association with disease severity: a cross-sectional study
Association of constipation with functional dependence among older adults with dementia: a cross-sectional analytical study
Prevalence of swallowing difficulty among adults with Alzheimer disease: a cross-sectional observational study
Association of dysphagia with nutritional impairment among patients with dementia: a cross-sectional analytical study
Comparison of nutritional parameters between dementia patients with and without dysphagia: a comparative cross-sectional study
Clinical profile of adults presenting with rapidly progressive cognitive decline to a tertiary care medicine department: a cross-sectional observational study
Aetiological spectrum of dementia among older adults attending a tertiary care hospital: a cross-sectional study
Comparison of clinical characteristics of Alzheimer disease and vascular dementia among older adults: a comparative cross-sectional study
Association of vascular risk-factor burden with severity of cognitive impairment among older adults with dementia: a cross-sectional analytical study
Comparison of executive, memory, and visuospatial impairment in Alzheimer disease and vascular dementia: a comparative cross-sectional study
Prevalence of mixed dementia among older adults evaluated for cognitive decline: a cross-sectional observational study
Association of cerebral small-vessel disease burden on neuroimaging with cognitive impairment among older adults with dementia: a cross-sectional analytical study
Comparison of functional dependence in Alzheimer disease, vascular dementia, and mixed dementia: a comparative cross-sectional study
Relationship between medial temporal lobe atrophy on neuroimaging and cognitive severity among adults with Alzheimer disease: a cross-sectional observational study
Association of global cerebral atrophy with functional impairment among older adults with dementia: a cross-sectional analytical study
Comparison of cognitive performance between patients with predominant cortical and subcortical neuroimaging changes: a comparative cross-sectional study
Prevalence of potentially reversible metabolic contributors among adults presenting with dementia syndrome: a cross-sectional study
Clinical, nutritional, metabolic, cognitive, and functional profile of older adults with dementia attending a tertiary care medicine service: a cross-sectional observational study
Motor Neuron Disease
Clinical profile and pattern of neurological involvement among adults with motor neuron disease: a cross-sectional observational study
Distribution of limb-onset and bulbar-onset motor neuron disease among adults attending a tertiary care hospital: a cross-sectional study
Comparison of clinical characteristics of limb-onset and bulbar-onset motor neuron disease: a comparative cross-sectional study
Association of age at symptom onset with functional disability among adults with motor neuron disease: a cross-sectional analytical study
Relationship between duration of symptoms and functional impairment among patients with motor neuron disease: a cross-sectional observational study
Prevalence of respiratory symptoms among adults with motor neuron disease: a cross-sectional study
Association of respiratory symptom burden with functional disability among adults with motor neuron disease: a cross-sectional analytical study
Relationship between bedside respiratory parameters and functional severity among patients with motor neuron disease: a cross-sectional observational study
Comparison of respiratory impairment between bulbar-onset and limb-onset motor neuron disease: a comparative cross-sectional study
Prevalence of orthopnea among adults with motor neuron disease and its association with respiratory muscle weakness: a cross-sectional study
Association of resting oxygen saturation with respiratory symptom burden among patients with motor neuron disease: a cross-sectional analytical study
Prevalence of swallowing difficulty among adults with motor neuron disease: a cross-sectional observational study
Association of dysphagia severity with nutritional status among patients with motor neuron disease: a cross-sectional analytical study
Comparison of nutritional parameters between motor neuron disease patients with and without bulbar involvement: a comparative cross-sectional study
Prevalence of undernutrition among adults with motor neuron disease and its association with functional impairment: a cross-sectional study
Association of body mass index with functional severity among adults with motor neuron disease: a cross-sectional analytical study
Relationship between mid-upper arm circumference and functional status among patients with motor neuron disease: a cross-sectional observational study
Comparison of anthropometric indices between patients with mild and severe motor neuron disease: a comparative cross-sectional study
Prevalence of anaemia among adults with motor neuron disease and its association with functional disability: a cross-sectional study
Association of serum albumin concentration with nutritional and functional status among patients with motor neuron disease: a cross-sectional analytical study
Prevalence of vitamin D deficiency among adults with motor neuron disease: a cross-sectional observational study
Association of serum vitamin D concentration with muscle weakness severity among adults with motor neuron disease: a cross-sectional analytical study
Prevalence of vitamin B12 deficiency among adults with suspected motor neuron disease: a cross-sectional study
Comparison of biochemical nutritional parameters between patients with bulbar and non-bulbar motor neuron disease: a comparative cross-sectional study
Prevalence of cognitive impairment among adults with motor neuron disease: a cross-sectional observational study
Association of executive dysfunction with functional severity among patients with motor neuron disease: a cross-sectional analytical study
Comparison of cognitive performance between motor neuron disease patients with and without bulbar involvement: a comparative cross-sectional study
Prevalence of behavioural symptoms among adults with motor neuron disease: a cross-sectional study
Association of behavioural abnormalities with executive dysfunction among patients with motor neuron disease: a cross-sectional analytical study
Prevalence of depressive symptoms among adults with motor neuron disease and their association with disability: a cross-sectional observational study
Association of anxiety symptoms with respiratory and swallowing impairment among patients with motor neuron disease: a cross-sectional analytical study
Comparison of psychological symptom burden between patients with early and advanced motor neuron disease: a comparative cross-sectional study
Prevalence of sleep disturbance among adults with motor neuron disease: a cross-sectional study
Association of sleep quality with respiratory symptoms among patients with motor neuron disease: a cross-sectional analytical study
Prevalence of cramps and fasciculations among adults with motor neuron disease and their association with disease severity: a cross-sectional observational study
Association of upper motor neuron signs with functional disability among adults with motor neuron disease: a cross-sectional analytical study
Comparison of clinical characteristics of patients with predominantly upper motor neuron and predominantly lower motor neuron involvement: a comparative cross-sectional study
Clinical profile of adults presenting with progressive muscular weakness suspected to have motor neuron disease: a cross-sectional observational study
Comparison of clinical and electrophysiological findings among different phenotypes of motor neuron disease: a comparative cross-sectional study
Clinical, respiratory, nutritional, cognitive, and functional profile of adults with motor neuron disease: a cross-sectional observational study
Atypical Parkinsonian Disorders
Clinical spectrum of atypical parkinsonian disorders among adults attending a tertiary care hospital: a cross-sectional observational study
Comparison of clinical characteristics of Parkinson disease and atypical parkinsonian disorders: a comparative cross-sectional study
Association of early postural instability with atypical parkinsonism among adults presenting with parkinsonian features: a cross-sectional analytical study
Association of early autonomic dysfunction with atypical parkinsonian disorders among adults with parkinsonism: a cross-sectional analytical study
Comparison of gait abnormalities between Parkinson disease and progressive supranuclear palsy: a comparative cross-sectional study
Clinical profile of progressive supranuclear palsy among adults attending a tertiary care centre: a cross-sectional observational study
Prevalence of falls among adults with progressive supranuclear palsy and their association with functional impairment: a cross-sectional study
Association of vertical gaze abnormality with disease severity among patients with progressive supranuclear palsy: a cross-sectional analytical study
Comparison of cognitive impairment between progressive supranuclear palsy and Parkinson disease: a comparative cross-sectional study
Prevalence of frontal executive dysfunction among adults with progressive supranuclear palsy: a cross-sectional observational study
Clinical profile of multiple system atrophy among adults presenting with atypical parkinsonism: a cross-sectional observational study
Prevalence of orthostatic hypotension among adults with multiple system atrophy: a cross-sectional study
Association of autonomic dysfunction severity with functional disability among patients with multiple system atrophy: a cross-sectional analytical study
Comparison of autonomic symptoms in multiple system atrophy and Parkinson disease: a comparative cross-sectional study
Prevalence of urinary dysfunction among adults with multiple system atrophy and its association with disease severity: a cross-sectional observational study
Comparison of parkinsonian and cerebellar phenotypes of multiple system atrophy: a comparative cross-sectional study
Clinical profile of corticobasal syndrome among adults attending a tertiary care hospital: a cross-sectional observational study
Association of cortical sensory deficits with functional disability among adults with corticobasal syndrome: a cross-sectional analytical study
Comparison of cognitive impairment in corticobasal syndrome and progressive supranuclear palsy: a comparative cross-sectional study
Prevalence of apraxia among adults with corticobasal syndrome and its association with disability: a cross-sectional study
Comparison of swallowing impairment across Parkinson disease, progressive supranuclear palsy, and multiple system atrophy: a comparative cross-sectional study
Comparison of orthostatic blood pressure abnormalities across Parkinson disease and atypical parkinsonian disorders: a comparative cross-sectional study
Association of early falls, dysphagia, and autonomic dysfunction with atypical parkinsonism among adults with parkinsonian syndromes: a cross-sectional analytical study
Comparison of nutritional status among patients with Parkinson disease, progressive supranuclear palsy, and multiple system atrophy: a comparative cross-sectional study
Clinical, cognitive, autonomic, and functional characteristics of common atypical parkinsonian disorders: a cross-sectional observational study
Frontotemporal Dementia
Clinical and behavioural profile of adults with frontotemporal dementia attending a tertiary care hospital: a cross-sectional observational study
Distribution of behavioural and language-predominant presentations among adults with frontotemporal dementia: a cross-sectional study
Comparison of clinical characteristics of behavioural variant frontotemporal dementia and Alzheimer disease: a comparative cross-sectional study
Association of age at symptom onset with behavioural severity among adults with frontotemporal dementia: a cross-sectional analytical study
Prevalence of disinhibition among adults with behavioural variant frontotemporal dementia: a cross-sectional observational study
Association of apathy with functional impairment among adults with frontotemporal dementia: a cross-sectional analytical study
Prevalence of altered eating behaviour among patients with frontotemporal dementia and its association with disease severity: a cross-sectional study
Association of compulsive behaviour with executive dysfunction among adults with frontotemporal dementia: a cross-sectional analytical study
Comparison of executive dysfunction between frontotemporal dementia and Alzheimer disease: a comparative cross-sectional study
Comparison of memory impairment between frontotemporal dementia and Alzheimer disease: a comparative cross-sectional study
Prevalence of language impairment among adults with frontotemporal dementia: a cross-sectional observational study
Comparison of clinical features of semantic and non-fluent language-predominant degenerative syndromes: a comparative cross-sectional study
Association of frontal lobe atrophy on neuroimaging with behavioural symptom burden in frontotemporal dementia: a cross-sectional analytical study
Comparison of neuroimaging patterns in frontotemporal dementia and Alzheimer disease: a comparative cross-sectional study
Prevalence of parkinsonian features among adults with frontotemporal dementia: a cross-sectional study
Association of parkinsonian features with functional impairment among patients with frontotemporal dementia: a cross-sectional analytical study
Prevalence of motor neuron features among adults with frontotemporal dementia: a cross-sectional observational study
Comparison of cognitive and behavioural manifestations in frontotemporal dementia with and without motor neuron features: a comparative cross-sectional study
Association of nutritional status with altered eating behaviour among adults with frontotemporal dementia: a cross-sectional analytical study
Clinical, behavioural, cognitive, nutritional, and neuroimaging profile of adults with frontotemporal dementia: a cross-sectional observational study
Dementia with Lewy Bodies
Clinical and cognitive profile of adults with dementia with Lewy bodies attending a tertiary care hospital: a cross-sectional observational study
Prevalence of visual hallucinations among adults with dementia with Lewy bodies: a cross-sectional study
Association of visual hallucination burden with cognitive severity among patients with dementia with Lewy bodies: a cross-sectional analytical study
Prevalence of cognitive fluctuations among adults with dementia with Lewy bodies: a cross-sectional observational study
Association of cognitive fluctuations with functional dependence among adults with dementia with Lewy bodies: a cross-sectional analytical study
Prevalence of parkinsonian features among adults with dementia with Lewy bodies: a cross-sectional study
Association of parkinsonian severity with functional disability among patients with dementia with Lewy bodies: a cross-sectional analytical study
Comparison of cognitive profile between dementia with Lewy bodies and Alzheimer disease: a comparative cross-sectional study
Comparison of visuospatial impairment between dementia with Lewy bodies and Alzheimer disease: a comparative cross-sectional study
Comparison of extrapyramidal manifestations between dementia with Lewy bodies and Parkinson disease dementia: a comparative cross-sectional study
Prevalence of probable rapid eye movement sleep behaviour disorder among adults with dementia with Lewy bodies: a cross-sectional observational study
Association of probable rapid eye movement sleep behaviour disorder with hallucinations in dementia with Lewy bodies: a cross-sectional analytical study
Prevalence of orthostatic hypotension among adults with dementia with Lewy bodies: a cross-sectional study
Association of autonomic dysfunction with functional dependence among patients with dementia with Lewy bodies: a cross-sectional analytical study
Comparison of autonomic symptom burden between dementia with Lewy bodies and Alzheimer disease: a comparative cross-sectional study
Prevalence of depressive and anxiety symptoms among adults with dementia with Lewy bodies: a cross-sectional observational study
Association of depressive symptoms with functional impairment among patients with dementia with Lewy bodies: a cross-sectional analytical study
Comparison of sleep disturbance between dementia with Lewy bodies and Alzheimer disease: a comparative cross-sectional study
Association of gait impairment and postural instability with falls among adults with dementia with Lewy bodies: a cross-sectional analytical study
Clinical, cognitive, neuropsychiatric, autonomic, and motor profile of adults with dementia with Lewy bodies: a cross-sectional observational study
Huntington Disease and Hereditary Choreiform Disorders
Clinical profile of adults with Huntington disease attending a tertiary care hospital: a cross-sectional observational study
Association of age at symptom onset with motor severity among adults with Huntington disease: a cross-sectional analytical study
Relationship between chorea severity and functional disability among patients with Huntington disease: a cross-sectional observational study
Prevalence of cognitive impairment among adults with Huntington disease: a cross-sectional study
Association of executive dysfunction with motor severity among patients with Huntington disease: a cross-sectional analytical study
Prevalence of depressive symptoms among adults with Huntington disease: a cross-sectional observational study
Association of depressive symptom burden with functional disability among patients with Huntington disease: a cross-sectional analytical study
Prevalence of behavioural abnormalities among adults with Huntington disease and their association with cognitive impairment: a cross-sectional study
Comparison of motor, cognitive, and behavioural characteristics of younger and older adults with Huntington disease: a comparative cross-sectional study
Association of nutritional status with disease severity among adults with Huntington disease: a cross-sectional analytical study
Prevalence of undernutrition among adults with Huntington disease: a cross-sectional observational study
Association of swallowing difficulty with nutritional impairment among patients with Huntington disease: a cross-sectional analytical study
Clinical profile of adults presenting with hereditary choreiform movements: a cross-sectional observational study
Comparison of clinical characteristics of Huntington disease and non-Huntington hereditary choreiform disorders: a comparative cross-sectional study
Clinical, cognitive, psychiatric, nutritional, and functional profile of adults with hereditary choreiform neurodegenerative disorders: a cross-sectional observational study
Spinocerebellar and Degenerative Ataxias
Clinical spectrum of adult-onset degenerative ataxias presenting to a tertiary care hospital: a cross-sectional observational study
Distribution of hereditary and sporadic degenerative ataxias among adults with chronic progressive ataxia: a cross-sectional study
Association of age at symptom onset with functional impairment among adults with degenerative ataxia: a cross-sectional analytical study
Relationship between gait ataxia severity and functional disability among adults with degenerative ataxia: a cross-sectional observational study
Comparison of clinical characteristics of hereditary and sporadic adult-onset degenerative ataxias: a comparative cross-sectional study
Prevalence of peripheral neuropathy among adults with spinocerebellar degeneration: a cross-sectional study
Association of peripheral neuropathy with gait impairment among adults with degenerative ataxia: a cross-sectional analytical study
Prevalence of pyramidal signs among adults with hereditary spinocerebellar ataxia: a cross-sectional observational study
Association of pyramidal signs with functional disability among adults with spinocerebellar degeneration: a cross-sectional analytical study
Prevalence of extrapyramidal manifestations among adults with degenerative ataxia: a cross-sectional study
Comparison of clinical characteristics of degenerative ataxia patients with and without extrapyramidal manifestations: a comparative cross-sectional study
Prevalence of cognitive impairment among adults with hereditary degenerative ataxia: a cross-sectional observational study
Association of executive dysfunction with functional disability among adults with degenerative ataxia: a cross-sectional analytical study
Prevalence of depressive symptoms among adults with degenerative ataxia and their association with disease severity: a cross-sectional study
Association of dysphagia with nutritional impairment among adults with degenerative ataxia: a cross-sectional analytical study
Comparison of nutritional status between patients with mild and severe degenerative ataxia: a comparative cross-sectional study
Prevalence of autonomic symptoms among adults with degenerative ataxia: a cross-sectional observational study
Association of orthostatic hypotension with functional severity among patients with degenerative ataxia: a cross-sectional analytical study
Comparison of clinical and functional characteristics of cerebellar-predominant and multisystem degenerative ataxias: a comparative cross-sectional study
Clinical, neurological, cognitive, autonomic, and functional profile of adults with degenerative ataxias: a cross-sectional observational study
Mild Cognitive Impairment and Early Neurodegenerative Cognitive Syndromes
Prevalence of mild cognitive impairment among older adults attending a general medicine outpatient department: a cross-sectional study
Clinical and cognitive profile of older adults with mild cognitive impairment: a cross-sectional observational study
Association of age and educational status with mild cognitive impairment among older adults: a cross-sectional analytical study
Comparison of demographic and clinical characteristics of older adults with and without mild cognitive impairment: a comparative cross-sectional study
Association of hypertension with mild cognitive impairment among older adults: a cross-sectional analytical study
Prevalence of mild cognitive impairment among adults with type 2 diabetes mellitus: a cross-sectional study
Association of glycated haemoglobin with cognitive performance among adults with type 2 diabetes mellitus: a cross-sectional analytical study
Comparison of cognitive performance between older adults with and without diabetes mellitus: a comparative cross-sectional study
Association of metabolic syndrome with mild cognitive impairment among older adults: a cross-sectional analytical study
Prevalence of vitamin B12 deficiency among older adults with mild cognitive impairment: a cross-sectional observational study
Association of vitamin B12 status with cognitive performance among older adults with mild cognitive impairment: a cross-sectional analytical study
Prevalence of vitamin D deficiency among older adults with mild cognitive impairment: a cross-sectional study
Association of serum vitamin D concentration with cognitive performance among older adults: a cross-sectional analytical study
Association of anaemia with mild cognitive impairment among older adults attending a medicine outpatient department: a cross-sectional analytical study
Comparison of nutritional status between older adults with normal cognition and mild cognitive impairment: a comparative cross-sectional study
Association of frailty with mild cognitive impairment among older adults: a cross-sectional analytical study
Relationship between handgrip strength and cognitive performance among older adults: a cross-sectional observational study
Association of gait speed with mild cognitive impairment among community-dwelling older adults: a cross-sectional analytical study
Comparison of sleep quality between older adults with normal cognition and mild cognitive impairment: a comparative cross-sectional study
Association of depressive symptoms, sleep disturbance, frailty, and nutritional status with mild cognitive impairment among older adults: a cross-sectional analytical study
Cross-Cutting Neurodegenerative Disease Syndromes and Comorbidities
Comparison of nutritional impairment across Parkinson disease, dementia, and motor neuron disease: a comparative cross-sectional study
Comparison of vitamin B12 deficiency among adults with Parkinson disease, dementia, and motor neuron disease: a comparative cross-sectional study
Comparison of vitamin D deficiency among adults with common neurodegenerative disorders: a comparative cross-sectional study
Association of frailty with functional dependence among older adults with neurodegenerative diseases: a cross-sectional analytical study
Comparison of frailty prevalence among patients with Parkinson disease, Alzheimer disease, and dementia with Lewy bodies: a comparative cross-sectional study
Association of sarcopenia with functional disability among older adults with neurodegenerative disease: a cross-sectional analytical study
Comparison of handgrip strength among adults with Parkinson disease, dementia, and age-matched individuals without neurodegenerative disease: a comparative cross-sectional study
Prevalence of polypharmacy among older adults with neurodegenerative disorders and its association with falls: a cross-sectional study
Association of potentially inappropriate medication use with orthostatic symptoms among older adults with neurodegenerative disease: a cross-sectional analytical study
Comparison of fall risk among adults with Parkinson disease, dementia, and atypical parkinsonian disorders: a comparative cross-sectional study
Prevalence of dysphagia among adults with common neurodegenerative disorders: a cross-sectional observational study
Comparison of swallowing difficulty among Parkinson disease, motor neuron disease, and atypical parkinsonian disorders: a comparative cross-sectional study
Association of dysphagia with nutritional impairment across common neurodegenerative diseases: a cross-sectional analytical study
Prevalence of orthostatic hypotension among adults with Parkinson disease, dementia with Lewy bodies, and multiple system atrophy: a cross-sectional study
Comparison of autonomic symptom burden among common neurodegenerative disorders presenting to a tertiary care hospital: a comparative cross-sectional study
Association of sleep disturbance with functional disability among adults with neurodegenerative diseases: a cross-sectional analytical study
Comparison of depressive symptom burden among adults with Parkinson disease, dementia, and motor neuron disease: a comparative cross-sectional study
Association of anaemia, hypoalbuminemia, and vitamin deficiencies with functional impairment among adults with neurodegenerative disorders: a cross-sectional analytical study
Comparison of cognitive, nutritional, gait, and functional abnormalities among older adults with Parkinson disease and major degenerative dementias: a comparative cross-sectional study
Spectrum of neurological, cognitive, autonomic, nutritional, sleep-related, and functional abnormalities among adults with common neurodegenerative diseases attending a tertiary care medicine department: a cross-sectional observational study
Not the general medicine subspeciality you need? Neurodegenerative diseases is one section of our full general medicine collection — the hub page lists every subspeciality, each with its own free topic list. Updated September 2026.
📌 Updated for 2026–2027 MD Medicine/DNB Medicine Neurodegenerative Diseases admissions
The page has been reviewed for feasibility in postgraduate medicine departments where most neurodegenerative research depends on structured clinical phenotyping, validated rating scales and routinely available investigations.
Most projects can be completed with neurological examination, cognition and function scales, routine blood tests, gait or autonomic assessment and standard CT or MRI performed as part of clinical care.
Genetic panels, advanced molecular biomarkers, PET imaging and research-only neurophysiology are not required for most practical dissertation designs.
Publication potential is strongest when the protocol defines the syndrome precisely, uses named validated scales and records medication state, education, disease duration and major comorbidities that can distort measured impairment.
Generate a protocol from any topic above
Select Generate Protocol → beside any title in the list above and receive a submission-ready document built around that topic, containing all eighteen components:
Introduction / Synopsis
Research Question
Aim of the Study
Primary Objective
Secondary Objectives
Materials and Methods
Inclusion Criteria
Exclusion Criteria
Sample Size Calculation
Methodology
Statistical Analysis
Ethical Considerations
Review of Literature
References
Gantt Chart / Study Timeline
Patient Information Sheet
Consent Form
Data Collection Form
Already have your thesis title?
Generate the full neurodegenerative diseases protocol directly — objectives, methodology, sample size, statistics, timeline, references and annexures.
Alongside neurodegenerative diseases protocols and synopses, support is also available for departmental presentations, journal club presentations, ethics committee presentations, and posters and oral presentations for medical conferences — for postgraduate residents, board trainees and research scholars across India and the GCC. Prepared by a practising doctor with long experience in medical publishing and thesis supervision.
The topics above work as research questions anywhere — what changes is the document the institution expects, and who approves it before data collection begins. The Gulf equivalent of an Indian synopsis is the neurodegenerative diseases research proposal submitted to an institutional review board, and it ordinarily carries three sections an Indian synopsis does not: a Gantt chart, a budget and resources section, and a Declaration of Helsinki statement.
Board and residency programmes — country by country
Saudi Arabia — SCFHS and the Saudi Board. Residency and fellowship training under the Saudi Commission for Health Specialties includes a research project with a set timeline, and the neurodegenerative diseases research proposal is the document prepared at the outset and cleared by the institutional review board before recruitment starts.
United Arab Emirates — DHA, DOH Abu Dhabi and MOHAP. Residents training in Dubai, Abu Dhabi and the northern emirates prepare a neurodegenerative diseases research protocol for their programme and submit it for institutional review board approval before any data are collected.
Qatar — DHP (formerly QCHP) and Hamad Medical Corporation. A neurodegenerative diseases IRB proposal is reviewed before recruitment, with the ethics section written to the institution's own template rather than a generic one.
Bahrain — NHRA. Trainees turning neurodegenerative diseases research topics into a project need the proposal cleared by their institutional research and ethics committee before fieldwork begins.
Oman — OMSB. Residency programmes under the Oman Medical Specialty Board include a research component, and the neurodegenerative diseases research proposal is the document assessed at the start of it.
Kuwait — KIMS. A neurodegenerative diseases study protocol goes to the institutional committee for approval before the project begins.
Arab Board programmes across the region. The Arab Board carries its own research requirement irrespective of the host country, and the neurodegenerative diseases proposal follows the same structure throughout.
Postgraduate degrees — Malaysia, the Gulf and beyond
Malaysia — MMed, the National Medical Research Register and MREC. A neurodegenerative diseases dissertation proposal for a Master of Medicine programme carried out in a Ministry of Health facility must be registered on the NMRR and approved by the Medical Research and Ethics Committee before the study begins, and the guidance asks for submission four to six months ahead of data collection. Every investigator on the study team registers on the NMRR as well, so the methodology, ethics and team sections are written in far more detail than an Indian synopsis requires.
PhD and Master's candidates elsewhere. University programmes generally require a full neurodegenerative diseases research proposal of roughly 6,000 to 10,000 words, with an extended literature review, a theoretical framework and a detailed methodology chapter.
PhD and MMed proposals are written individually by a medical doctor and revised until the supervisor accepts them. They are not produced by the automated protocol generator.
🔥 Trending research areas in Neurodegenerative Diseases for 2026–27
Current dissertation opportunities increasingly focus on multidomain clinical phenotyping, early functional markers and reproducible bedside measures rather than descriptive case profiles alone.
Non-motor burden in Parkinson disease: cognition, sleep, autonomic dysfunction, mood and nutrition can be studied using validated scales and often explain disability beyond motor severity.
Frailty, sarcopenia and gait: these measures are increasingly useful across dementia and parkinsonian disorders because they connect neurological disease with falls, dependence and hospital outcomes.
Clinical-imaging correlation: medial temporal atrophy, small-vessel disease burden and regional atrophy patterns are useful when imaging ratings are predefined and interpreted independently of the cognitive score being correlated.
Phenotype differentiation: comparative work between Parkinson disease, atypical parkinsonism and major dementia syndromes can be valuable when diagnostic criteria and red-flag features are fixed before enrolment.
Protocol and synopsis guidance
What a Neurodegenerative Diseases protocol must contain
Case definition: State the clinical criteria used to classify Parkinson disease, Alzheimer disease, dementia with Lewy bodies, motor neuron disease, atypical parkinsonism or another syndrome. Avoid relying only on a previous chart label, particularly when phenotypes overlap.
Measurement instrument: Name the exact motor, cognitive, behavioural, autonomic or functional scale and the version or language used. A score is interpretable only if the protocol states who administers it, under what conditions and how missing items are handled.
Medication state: In Parkinson disease and related disorders, motor examination can differ substantially between medication ON and OFF states. The protocol should fix the examination state rather than mix measurements obtained at arbitrary times after dopaminergic therapy.
Education and sensory confounding: Cognitive scores are influenced by education, literacy, vision, hearing and language. These factors must be recorded because a low score does not automatically represent neurodegenerative cognitive decline.
Function versus impairment: Functional dependence can be caused by motor disability, frailty, arthritis, stroke or sensory loss as well as cognition. The protocol should distinguish the neurological construct being measured from general disability.
Neurodegenerative Diseases synopsis versus Neurodegenerative Diseases protocol
Synopsis: The synopsis should state the target neurodegenerative syndrome, study design, principal scale or measurement, main exposure or comparison and the primary outcome in a concise form suitable for academic review.
Protocol: The protocol must define diagnostic criteria, medication state where relevant, examiner training, scale version, language, education adjustment, imaging interpretation method, confounders and the precise time point of assessment.
Why the distinction matters: A synopsis may say that cognitive impairment will be associated with Parkinson disease severity, but the protocol must specify which cognitive test is used, whether education-adjusted thresholds are applied, whether testing occurs during a defined medication state and how depression, hearing impairment or delirium will be excluded.
Sample size and statistical analysis
Base the calculation on the primary objective: Estimating prevalence of cognitive impairment, comparing two phenotypes, correlating a motor score with disability and identifying predictors of falls each require different sample-size assumptions.
Respect scale structure: Ordinal motor or functional scores should not automatically be treated as normally distributed continuous variables. Distribution, ceiling effects and floor effects should be checked before choosing parametric tests.
Control major confounders: Age, sex, education, disease duration, medication burden, vascular risk factors, depression, frailty and sensory impairment can alter cognition and function. Multivariable analysis should be planned when these variables are central to the research question.
Avoid circular correlations: If a severity scale already contains gait, falls or activities-of-daily-living items, correlating that total score with another measure containing the same items may produce an inflated association. Overlapping constructs should be identified before analysis.
1. How do I choose a feasible Neurodegenerative Diseases topic for the 2026–2027 academic year?
Choose a syndrome with sufficient case volume in your medicine or neurology service and a question that can be answered with routinely available clinical assessment. Parkinson disease, common dementias and mixed neurodegenerative clinics usually provide more realistic recruitment than very rare hereditary disorders. Prefer one primary domain such as cognition, gait, autonomic dysfunction, nutrition or functional disability rather than combining many unrelated outcomes into one dissertation.
2. Which study designs are usually accepted for a Neurodegenerative Diseases dissertation?
Commonly feasible designs include cross-sectional observational and analytical studies, comparative studies between well-defined clinical phenotypes, retrospective record-based cohorts, prospective cohorts with a short functional outcome and case-control designs for selected associations. Diagnostic differentiation studies are possible if every group is classified using predefined criteria rather than clinician impression alone.
3. What should I settle with my guide before finalising a Neurodegenerative Diseases topic?
Agree on the exact diagnostic criteria, primary scale, language version, assessor, medication state, cognitive exclusion criteria, imaging variables, expected case load and the primary statistical comparison. These choices should be fixed before recruitment because changing scales or case definitions midway makes interpretation difficult.
4. Can I use routine cognitive and functional scales in a Neurodegenerative Diseases thesis?
Yes, provided the instrument is validated for the population and the protocol specifies how it is administered. Education, literacy, hearing, vision, depression and language can alter cognitive performance, while physical disability can alter functional scores independently of cognition. These influences should be measured or controlled rather than treated as noise.
5. What is the difference between a Neurodegenerative Diseases synopsis and a Neurodegenerative Diseases protocol?
The synopsis presents the research question, target syndrome, study design, principal variables and broad analysis plan. The protocol converts that idea into a reproducible method by defining diagnostic criteria, scale administration, medication state, examiner procedures, confounders, imaging assessment, sample size and statistical methods.
6. What ethical issues should I address in a Neurodegenerative Diseases study?
Cognitive impairment may affect capacity to consent, so the protocol should state how decision-making capacity will be assessed and when a legally acceptable representative will provide consent. Participants who retain capacity should consent directly. If children are exceptionally included in a hereditary disorder study, guardian consent and child assent from about seven years should be addressed. Record-based work may qualify for an ethics-approved waiver of consent.
No additional radiation, contrast study, research-only MRI sequence or research-only venepuncture should be added unless scientifically necessary and ethically approved. If extra blood sampling is required, the protocol should state the blood-volume limit. Separate consent should be obtained for identifiable photographs or video of gait, tremor or movement phenomenology. Incidental clinically important findings on neuroimaging or laboratory testing should have a named escalation pathway to the treating clinician. Imaging datasets should be anonymised because DICOM headers and reconstructed facial surfaces can contain identifiers.
7. How do I avoid misclassifying severity in Parkinson disease and dementia research?
Use a named validated scale and standardise the conditions under which it is applied. In Parkinson disease, motor severity should be assessed in a predefined medication state because an examination performed soon after levodopa cannot be compared directly with one performed when the patient is OFF medication. In dementia research, cognitive scores should be interpreted with education, literacy, language, hearing, vision and mood in mind. Functional dependence should not be assumed to represent cognitive severity because gait impairment, frailty, stroke and musculoskeletal disease can independently reduce activities of daily living.
8. Can a Neurodegenerative Diseases dissertation later support a PhD or Gulf board research pathway?
Yes, but the scope and documentation differ. An MD or DNB synopsis is usually a time-limited residency dissertation plan, whereas a PhD proposal generally requires a broader research programme, stronger justification of the knowledge gap and more extensive methodology. Gulf pathways may separately require a board research project or proposal under SCFHS and the Saudi Board, the Arab Board of Health Specializations, or DHP, DHA, DOH and MOHAP-linked programmes. The same clinical question may sometimes be adapted, but supervision, ethics, format and institutional requirements should be checked for the specific programme.
9. When should I register my Neurodegenerative Diseases dissertation?
Register after the diagnostic criteria, principal scale, primary objective, sample-size basis and expected recruitment rate have been agreed with the guide. It is particularly important to confirm that the selected syndrome appears frequently enough in the department and that the chosen assessment tool can be administered consistently throughout the study period.
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