Glaucoma Thesis Topics for MS Ophthalmology/DNB Ophthalmology
This page brings together glaucoma thesis topics for MS Ophthalmology across primary open angle glaucoma, primary angle closure disease, screening, optical coherence tomography, visual fields, tonometry, medical treatment, adherence, secondary glaucoma and surgical outcomes. The topics are intended for MS Ophthalmology residents and are framed around designs that can usually be completed within one thesis period using routine glaucoma clinic patients, gonioscopy, applanation tonometry, standard automated perimetry, optic-disc assessment and optical coherence tomography already available in a teaching hospital. The strongest glaucoma research topics for MS Ophthalmology define whether the primary outcome is structural, functional, pressure-related or angle-related and avoid treating a single test as a complete diagnostic standard. Once a topic is shortlisted, the MS Ophthalmology glaucoma protocol and MS Ophthalmology glaucoma synopsis should specify the glaucoma definition, measurement conditions, reference standard, study-eye rule and statistical plan.
Last reviewed and updated: September 2026 · 2026–27 admissions
Primary Open Angle Glaucoma
Association of central corneal thickness with glaucoma severity in newly diagnosed primary open angle glaucoma, using visual field mean deviation as outcome: cross-sectional analytical study.
Correlation of intraocular pressure with visual field damage in untreated primary open angle glaucoma, using standard automated perimetry as reference: cross-sectional correlation study.
Relationship between age and retinal nerve fibre layer thickness in primary open angle glaucoma, measured by optical coherence tomography: cross-sectional analytical study.
Association of systemic hypertension with severity of optic nerve damage in primary open angle glaucoma, assessed by cup-to-disc ratio and visual field loss: comparative cross-sectional study.
Association of diabetes mellitus with retinal nerve fibre layer thickness in patients with primary open angle glaucoma, measured by optical coherence tomography: comparative cross-sectional study.
Correlation between vertical cup-to-disc ratio and visual field mean deviation in treatment-naive primary open angle glaucoma: hospital-based cross-sectional correlation study.
Relationship between baseline intraocular pressure and retinal nerve fibre layer thickness in newly diagnosed primary open angle glaucoma: cross-sectional analytical study.
Association of family history with severity at presentation in newly diagnosed primary open angle glaucoma, assessed by visual field and optic disc damage: cross-sectional study.
Comparison of glaucoma severity at diagnosis between symptomatic and incidentally detected primary open angle glaucoma patients using standard automated perimetry: comparative cross-sectional study.
Association of refractive error with optic disc and visual field characteristics in primary open angle glaucoma: cross-sectional analytical study.
Correlation of ganglion cell complex thickness with visual field mean deviation in primary open angle glaucoma using optical coherence tomography: cross-sectional correlation study.
Comparison of retinal nerve fibre layer thickness between early and moderate primary open angle glaucoma using spectral domain optical coherence tomography: comparative cross-sectional study.
Association between axial length and retinal nerve fibre layer thickness in primary open angle glaucoma patients: cross-sectional analytical study.
Relationship between duration of diagnosed glaucoma and severity of visual field loss in patients receiving topical treatment: cross-sectional analytical study.
Comparison of optic disc parameters between primary open angle glaucoma patients with and without diabetes mellitus: comparative cross-sectional study.
Association of body mass index with intraocular pressure in adults with primary open angle glaucoma attending a tertiary hospital: cross-sectional analytical study.
Correlation between pattern standard deviation and retinal nerve fibre layer thickness in early primary open angle glaucoma: cross-sectional correlation study.
Comparison of glaucoma severity between patients younger and older than sixty years with newly diagnosed primary open angle glaucoma: comparative cross-sectional study.
Association of presenting intraocular pressure with advanced visual field loss in newly diagnosed primary open angle glaucoma: cross-sectional analytical study.
Diagnostic accuracy of optic disc examination for detecting primary open angle glaucoma against standard automated perimetry and optical coherence tomography: diagnostic accuracy study.
Primary Angle Closure Disease
Association of anterior chamber depth with severity of primary angle closure disease, using gonioscopic angle grading as reference: cross-sectional analytical study.
Correlation of axial length with gonioscopic angle width in patients with primary angle closure disease: cross-sectional correlation study.
Comparison of central corneal thickness between primary angle closure glaucoma and primary open angle glaucoma patients: comparative cross-sectional study.
Association of hypermetropic refractive error with primary angle closure disease severity, assessed by gonioscopy and optic nerve damage: cross-sectional analytical study.
Relationship between age and extent of angle closure in newly diagnosed primary angle closure suspects using gonioscopy: cross-sectional analytical study.
Comparison of ocular biometric parameters between primary angle closure suspects and healthy controls using optical biometry: comparative cross-sectional study.
Correlation of anterior chamber depth measured clinically and by optical biometry in patients at risk of angle closure: observer agreement study.
Diagnostic accuracy of van Herick anterior chamber depth grading for detecting occludable angles using gonioscopy as reference standard: diagnostic accuracy study.
Agreement between van Herick grading and gonioscopic angle assessment in patients suspected to have primary angle closure disease: agreement study.
Association of lens thickness with angle closure severity in primary angle closure disease using optical biometry and gonioscopy: cross-sectional analytical study.
Comparison of retinal nerve fibre layer thickness between primary angle closure glaucoma and primary open angle glaucoma with similar visual field loss: comparative cross-sectional study.
Correlation between intraocular pressure and extent of peripheral anterior synechiae in primary angle closure glaucoma: cross-sectional correlation study.
Association of presenting symptoms with severity of optic nerve damage in newly diagnosed primary angle closure glaucoma: cross-sectional analytical study.
Comparison of visual field patterns in primary angle closure glaucoma and primary open angle glaucoma matched for disease severity: comparative cross-sectional study.
Association of cataract grade with anterior chamber depth in patients with primary angle closure disease awaiting cataract surgery: cross-sectional analytical study.
Change in intraocular pressure twelve weeks after laser peripheral iridotomy in primary angle closure suspects with occludable angles: prospective observational study.
Change in gonioscopic angle width after laser peripheral iridotomy in primary angle closure suspects assessed at four weeks: prospective observational study.
Predictors of persistent angle closure after laser peripheral iridotomy in patients with primary angle closure disease: prospective observational study.
Comparison of intraocular pressure before and after cataract surgery in patients with coexisting cataract and primary angle closure disease at six weeks: prospective observational study.
Association of delayed presentation with advanced visual field loss in patients with newly diagnosed primary angle closure glaucoma: cross-sectional analytical study.
Glaucoma Diagnostics and Screening
Diagnostic accuracy of non-contact tonometry for detecting raised intraocular pressure using Goldmann applanation tonometry as reference standard in glaucoma suspects: diagnostic accuracy study.
Agreement between non-contact tonometry and Goldmann applanation tonometry in patients attending a glaucoma clinic: device agreement study.
Diagnostic accuracy of direct ophthalmoscopic cup-to-disc ratio assessment for detecting glaucomatous optic neuropathy using fundus photography as reference: diagnostic accuracy study.
Agreement between clinical optic disc examination and fundus photograph grading for vertical cup-to-disc ratio in glaucoma suspects: observer agreement study.
Diagnostic accuracy of retinal nerve fibre layer thickness for detecting early glaucoma using standard automated perimetry and clinical optic nerve assessment as reference: diagnostic accuracy study.
Diagnostic accuracy of ganglion cell complex thickness for identifying early glaucomatous damage in glaucoma suspects using standard automated perimetry as reference: diagnostic accuracy study.
Comparison of retinal nerve fibre layer and ganglion cell complex parameters for detecting early primary open angle glaucoma: comparative cross-sectional study.
Diagnostic accuracy of visual field testing for glaucoma detection in patients with suspicious optic discs using combined structural assessment as reference: diagnostic accuracy study.
Agreement between two ophthalmologists in gonioscopic grading of anterior chamber angles among glaucoma suspects: inter-observer reliability study.
Intra-observer repeatability of gonioscopic angle grading in patients evaluated for primary angle closure disease: intra-observer reliability study.
Diagnostic accuracy of flashlight anterior chamber depth assessment for identifying occludable angles using gonioscopy as reference standard: diagnostic accuracy study.
Screening yield of comprehensive glaucoma evaluation among first-degree relatives of patients with primary glaucoma attending a tertiary hospital: cross-sectional screening study.
Prevalence of previously undiagnosed glaucoma among adults attending a general ophthalmology outpatient department and associated clinical predictors: cross-sectional observational study.
Diagnostic yield of opportunistic glaucoma screening among adults aged forty years and above attending cataract services: cross-sectional screening study.
Association of suspicious optic disc appearance with confirmed glaucoma among patients referred from general ophthalmology clinics: cross-sectional analytical study.
Diagnostic accuracy of vertical cup-to-disc ratio threshold for detecting glaucomatous visual field loss in adults with glaucoma suspicion: diagnostic accuracy study.
Agreement between optic disc photography and optical coherence tomography classification in identifying glaucomatous optic nerve damage: device agreement study.
Diagnostic accuracy of intraocular pressure measurement alone for identifying glaucoma among adults referred for glaucoma evaluation: diagnostic accuracy study.
Predictors of confirmed glaucoma among patients referred because of raised intraocular pressure detected during routine eye examination: cross-sectional analytical study.
Diagnostic yield of combined intraocular pressure, optic disc and gonioscopy screening compared with intraocular pressure screening alone in adults over forty years: comparative cross-sectional study.
Optical Coherence Tomography in Glaucoma
Correlation of average retinal nerve fibre layer thickness with visual field mean deviation in primary open angle glaucoma: cross-sectional correlation study.
Correlation of inferior retinal nerve fibre layer thickness with superior visual field loss in patients with primary open angle glaucoma: cross-sectional correlation study.
Correlation of superior retinal nerve fibre layer thickness with inferior visual field loss in patients with primary open angle glaucoma: cross-sectional correlation study.
Association of ganglion cell complex thickness with glaucoma severity classified by standard automated perimetry: cross-sectional analytical study.
Comparison of retinal nerve fibre layer thickness between glaucoma suspects and early primary open angle glaucoma patients: comparative cross-sectional study.
Comparison of ganglion cell complex thickness between glaucoma suspects and early primary open angle glaucoma patients: comparative cross-sectional study.
Diagnostic accuracy of macular ganglion cell complex analysis for detecting early glaucoma using visual field and optic disc assessment as reference: diagnostic accuracy study.
Relationship between optic disc area and retinal nerve fibre layer thickness measurements in glaucoma suspects: cross-sectional analytical study.
Association of axial length with retinal nerve fibre layer thickness measurements in myopic patients undergoing glaucoma evaluation: cross-sectional analytical study.
Comparison of retinal nerve fibre layer thickness in myopic glaucoma and non-myopic glaucoma patients matched for visual field severity: comparative cross-sectional study.
Correlation of minimum neuroretinal rim width with visual field mean deviation in patients with primary open angle glaucoma: cross-sectional correlation study.
Agreement between retinal nerve fibre layer and ganglion cell complex classifications for identifying glaucomatous damage in glaucoma suspects: agreement study.
Association of central corneal thickness with structural glaucoma severity measured by retinal nerve fibre layer thickness: cross-sectional analytical study.
Comparison of optical coherence tomography parameters between primary angle closure glaucoma and primary open angle glaucoma with matched visual field severity: comparative cross-sectional study.
Relationship between age and ganglion cell complex thickness among healthy adults used as glaucoma controls: cross-sectional analytical study.
Diagnostic accuracy of quadrant retinal nerve fibre layer thickness abnormalities for detecting early primary open angle glaucoma: diagnostic accuracy study.
Correlation between cup-to-disc ratio measured clinically and optic nerve head parameters measured by optical coherence tomography in glaucoma patients: correlation study.
Agreement between clinical glaucoma staging and optical coherence tomography severity classification in primary open angle glaucoma: agreement study.
Association of visual field defect location with corresponding retinal nerve fibre layer sector thinning in primary open angle glaucoma: cross-sectional analytical study.
Diagnostic performance of combined retinal nerve fibre layer and ganglion cell analysis compared with either parameter alone for early glaucoma detection: diagnostic accuracy study.
Visual Fields and Functional Assessment
Correlation between visual field mean deviation and clinical optic disc damage in primary open angle glaucoma: cross-sectional correlation study.
Correlation between visual field mean deviation and retinal nerve fibre layer thickness in primary angle closure glaucoma: cross-sectional correlation study.
Comparison of visual field defect patterns between primary open angle glaucoma and primary angle closure glaucoma: comparative cross-sectional study.
Association of intraocular pressure at presentation with visual field mean deviation in newly diagnosed glaucoma patients: cross-sectional analytical study.
Relationship between visual field severity and self-reported difficulty in daily activities among patients with bilateral glaucoma: cross-sectional analytical study.
Association of better-eye visual field mean deviation with vision-related quality of life in patients with bilateral glaucoma: cross-sectional analytical study.
Association of worse-eye visual field loss with fear of falling among elderly patients with glaucoma: cross-sectional analytical study.
Comparison of visual field severity between patients diagnosed through routine screening and those presenting with visual symptoms: comparative cross-sectional study.
Correlation between vertical cup-to-disc ratio and visual field index in patients with established primary open angle glaucoma: cross-sectional correlation study.
Association of duration of glaucoma treatment with visual field severity at tertiary-care presentation: cross-sectional analytical study.
Agreement between two consecutive reliable standard automated perimetry examinations in newly diagnosed glaucoma patients: test-retest reliability study.
Frequency and determinants of unreliable standard automated perimetry among glaucoma patients undergoing their first visual field examination: cross-sectional analytical study.
Association of age with fixation losses and false responses during standard automated perimetry in glaucoma patients: cross-sectional analytical study.
Comparison of visual field reliability between first-time and previously experienced perimetry patients with glaucoma: comparative cross-sectional study.
Association of advanced visual field loss with delayed glaucoma diagnosis among patients attending a tertiary referral centre: cross-sectional analytical study.
Correlation of visual field pattern standard deviation with structural optic nerve damage in early glaucoma: cross-sectional correlation study.
Comparison of visual field indices in primary open angle glaucoma patients with and without systemic hypertension: comparative cross-sectional study.
Comparison of visual field indices in primary open angle glaucoma patients with and without diabetes mellitus: comparative cross-sectional study.
Association of bilateral visual field impairment with dependence in activities of daily living among elderly glaucoma patients: cross-sectional analytical study.
Relationship between visual field severity and best corrected visual acuity in patients with advanced glaucoma: cross-sectional correlation study.
Intraocular Pressure and Tonometry
Agreement between Goldmann applanation tonometry and non-contact tonometry in newly diagnosed glaucoma patients across different central corneal thickness values: device agreement study.
Association of central corneal thickness with difference between Goldmann applanation and non-contact tonometry measurements in glaucoma suspects: cross-sectional analytical study.
Correlation between central corneal thickness and Goldmann applanation intraocular pressure in patients with primary open angle glaucoma: cross-sectional correlation study.
Comparison of intraocular pressure measured by Goldmann applanation tonometry between diabetic and non-diabetic glaucoma patients: comparative cross-sectional study.
Association of body mass index with intraocular pressure among adults undergoing glaucoma evaluation: cross-sectional analytical study.
Association of systemic blood pressure with intraocular pressure in patients with primary open angle glaucoma: cross-sectional analytical study.
Comparison of intraocular pressure between primary open angle glaucoma and primary angle closure glaucoma at first presentation: comparative cross-sectional study.
Relationship between intraocular pressure and visual field severity in untreated primary glaucoma: cross-sectional analytical study.
Relationship between intraocular pressure and retinal nerve fibre layer thickness in treatment-naive primary glaucoma: cross-sectional correlation study.
Agreement between two consecutive Goldmann applanation tonometry measurements by the same examiner in glaucoma patients: intra-observer reliability study.
Agreement between Goldmann applanation tonometry measurements obtained by two trained examiners in glaucoma patients: inter-observer reliability study.
Comparison of morning and afternoon intraocular pressure measurements in treated primary open angle glaucoma patients attending outpatient follow-up: prospective observational study.
Association of topical glaucoma medication number with clinic intraocular pressure among patients receiving long-term treatment: cross-sectional analytical study.
Change in intraocular pressure twelve weeks after initiation of first-line topical therapy in newly diagnosed primary open angle glaucoma: prospective observational study.
Comparison of intraocular pressure reduction after four weeks of latanoprost versus timolol monotherapy in treatment-naive primary open angle glaucoma: prospective comparative study.
Comparison of intraocular pressure reduction after four weeks of timolol versus brimonidine monotherapy in newly treated primary open angle glaucoma: prospective comparative study.
Association of corneal curvature with differences between Goldmann applanation and non-contact tonometry in glaucoma suspects: cross-sectional analytical study.
Effect of central corneal thickness categories on classification of ocular hypertension among glaucoma suspects: cross-sectional analytical study.
Prevalence of ocular hypertension among adults referred to a glaucoma clinic and associated ocular risk factors: cross-sectional observational study.
Predictors of inadequately controlled intraocular pressure among patients receiving topical glaucoma therapy for at least three months: cross-sectional analytical study.
Glaucoma Medical Treatment and Ocular Surface
Prevalence of dry eye disease among patients using topical glaucoma medications and association with number of medications: cross-sectional analytical study.
Association of duration of topical glaucoma treatment with tear film breakup time in patients receiving preserved eye drops: cross-sectional analytical study.
Comparison of ocular surface disease symptoms between patients using one and multiple topical glaucoma medications: comparative cross-sectional study.
Correlation between ocular surface disease questionnaire scores and number of topical glaucoma medications used daily: cross-sectional correlation study.
Association of benzalkonium chloride-containing glaucoma medications with tear film abnormalities compared with preservative-free therapy: comparative cross-sectional study.
Comparison of Schirmer test values between treated glaucoma patients and age-matched individuals not using topical eye drops: comparative cross-sectional study.
Association of topical medication duration with corneal staining severity among patients receiving glaucoma treatment: cross-sectional analytical study.
Relationship between frequency of daily eye-drop instillation and ocular surface symptoms in patients with medically treated glaucoma: cross-sectional analytical study.
Comparison of ocular surface parameters between patients using prostaglandin analogues and beta-blockers for glaucoma: comparative cross-sectional study.
Association of conjunctival hyperaemia with self-reported adherence among patients receiving prostaglandin analogue therapy: cross-sectional analytical study.
Frequency of local adverse effects among patients receiving topical glaucoma medications and their association with treatment adherence: cross-sectional analytical study.
Change in tear film parameters after three months of newly initiated topical glaucoma therapy in treatment-naive patients: prospective observational study.
Comparison of short-term intraocular pressure reduction between fixed-combination and separate-component topical glaucoma therapy in patients requiring two medications: prospective comparative study.
Association of medication-related ocular discomfort with missed doses among patients receiving long-term topical glaucoma therapy: cross-sectional analytical study.
Relationship between number of preserved glaucoma medications and conjunctival hyperaemia severity in treated patients: cross-sectional analytical study.
Comparison of ocular surface disease prevalence in glaucoma patients using preserved medications and untreated glaucoma suspects: comparative cross-sectional study.
Association of incorrect eye-drop instillation technique with inadequate intraocular pressure control among treated glaucoma patients: cross-sectional analytical study.
Effect of structured eye-drop technique counselling on correct instillation and intraocular pressure after four weeks in glaucoma patients: prospective observational study.
Association of systemic adverse symptoms with beta-blocker eye-drop use among glaucoma patients attending follow-up: cross-sectional analytical study.
Predictors of intolerance to topical glaucoma medications among patients attending a tertiary-care glaucoma clinic: cross-sectional analytical study.
Glaucoma Adherence, Awareness and Quality of Life
Prevalence of poor medication adherence among patients receiving topical glaucoma therapy and associated demographic and clinical factors: cross-sectional analytical study.
Association of glaucoma knowledge with medication adherence among patients receiving long-term topical treatment: cross-sectional analytical study.
Relationship between socioeconomic status and glaucoma medication adherence among patients attending a government tertiary-care hospital: cross-sectional analytical study.
Association of education level with awareness of irreversible vision loss among patients with newly diagnosed glaucoma: cross-sectional analytical study.
Association of travel distance to hospital with missed glaucoma follow-up visits among patients receiving long-term treatment: cross-sectional analytical study.
Predictors of follow-up default among glaucoma patients scheduled for review within six months at a tertiary-care hospital: prospective observational study.
Association of treatment cost with medication non-adherence among glaucoma patients receiving multiple topical medications: cross-sectional analytical study.
Relationship between family support and medication adherence among elderly patients with glaucoma: cross-sectional analytical study.
Association of eye-drop instillation difficulty with poor medication adherence among elderly glaucoma patients: cross-sectional analytical study.
Frequency of incorrect eye-drop instillation technique and its relationship with glaucoma control in patients using topical medications: cross-sectional analytical study.
Association of glaucoma severity with vision-related quality of life among patients with bilateral primary glaucoma: cross-sectional analytical study.
Relationship between better-eye visual field loss and vision-related quality of life among patients with advanced glaucoma: cross-sectional correlation study.
Association of glaucoma-related visual impairment with anxiety symptoms among patients attending a tertiary glaucoma clinic: cross-sectional analytical study.
Relationship between treatment burden and quality of life among patients using multiple glaucoma medications: cross-sectional analytical study.
Comparison of medication adherence between patients using once-daily and multiple-daily glaucoma treatment regimens: comparative cross-sectional study.
Association of counselling received at diagnosis with glaucoma knowledge among patients returning for follow-up: cross-sectional analytical study.
Assessment of reasons for delayed presentation among patients newly diagnosed with advanced glaucoma at a tertiary-care centre: cross-sectional observational study.
Association of rural residence with advanced glaucoma at first diagnosis among patients presenting to a tertiary government hospital: cross-sectional analytical study.
Determinants of missed glaucoma appointments among patients registered for long-term follow-up at a tertiary-care hospital: retrospective record-based study.
Effect of structured glaucoma counselling on medication adherence and disease knowledge after three months of follow-up: prospective observational study.
Secondary and Special Types of Glaucoma
Clinical profile and severity at presentation of pseudoexfoliation glaucoma among patients attending a tertiary glaucoma clinic: cross-sectional observational study.
Comparison of intraocular pressure and visual field severity between pseudoexfoliation glaucoma and primary open angle glaucoma: comparative cross-sectional study.
Association of lens pseudoexfoliative material with poor pupillary dilation among cataract patients undergoing glaucoma evaluation: cross-sectional analytical study.
Comparison of central corneal thickness between pseudoexfoliation glaucoma and primary open angle glaucoma patients: comparative cross-sectional study.
Correlation of retinal nerve fibre layer thickness with visual field loss in pseudoexfoliation glaucoma: cross-sectional correlation study.
Clinical profile of pigmentary glaucoma and pigment dispersion among patients attending a tertiary glaucoma clinic: retrospective observational study.
Prevalence of steroid-induced ocular hypertension among patients using topical corticosteroids for ocular inflammatory disorders: cross-sectional observational study.
Association of duration of topical corticosteroid use with intraocular pressure elevation in patients receiving treatment for ocular surface disease: cross-sectional analytical study.
Clinical profile and short-term intraocular pressure outcomes of uveitic glaucoma patients managed at a tertiary-care centre: prospective observational study.
Association of inflammation severity with intraocular pressure elevation in patients with active anterior uveitis: cross-sectional analytical study.
Prevalence of glaucoma among eyes with previous ocular trauma and associated clinical risk factors: retrospective record-based observational study.
Association of angle recession extent with intraocular pressure elevation following blunt ocular trauma: cross-sectional analytical study.
Clinical profile of neovascular glaucoma among patients presenting to a tertiary hospital and association with underlying retinal disease: cross-sectional observational study.
Comparison of presenting features of neovascular glaucoma associated with diabetic retinopathy and retinal vein occlusion: comparative cross-sectional study.
Association of diabetic retinopathy severity with neovascular glaucoma among patients with proliferative diabetic retinopathy: case-control study.
Clinical profile and intraocular pressure characteristics of lens-induced secondary glaucoma in patients presenting with advanced cataract: cross-sectional observational study.
Comparison of clinical presentation between phacomorphic and phacolytic glaucoma in patients with advanced cataract: comparative cross-sectional study.
Change in intraocular pressure six weeks after cataract extraction in patients presenting with phacomorphic glaucoma: prospective observational study.
Clinical characteristics and causes of secondary glaucoma following vitreoretinal procedures at a tertiary-care hospital: retrospective record-based study.
Prevalence and determinants of raised intraocular pressure among patients receiving repeated periocular corticosteroid therapy: cross-sectional analytical study.
Glaucoma Surgery, Laser and Postoperative Outcomes
Change in intraocular pressure and glaucoma medication requirement three months after trabeculectomy in patients with uncontrolled primary glaucoma: prospective observational study.
Association of preoperative intraocular pressure with three-month pressure reduction after trabeculectomy in patients with medically uncontrolled glaucoma: prospective observational study.
Change in best corrected visual acuity and intraocular pressure three months after combined cataract surgery and trabeculectomy in coexisting cataract and glaucoma: prospective observational study.
Comparison of three-month intraocular pressure outcomes after trabeculectomy in primary open angle and primary angle closure glaucoma: prospective comparative study.
Association of preoperative conjunctival medication exposure with early postoperative inflammation after trabeculectomy in patients with primary glaucoma: prospective observational study.
Frequency and predictors of early postoperative complications within six weeks after trabeculectomy for primary glaucoma: prospective observational study.
Relationship between postoperative anterior chamber depth and intraocular pressure during the first month after trabeculectomy: prospective observational study.
Change in corneal endothelial cell density three months after trabeculectomy in patients with primary glaucoma: prospective observational study.
Comparison of corneal endothelial cell density before and three months after combined cataract surgery and trabeculectomy: prospective observational study.
Change in intraocular pressure twelve weeks after laser peripheral iridotomy in patients with primary angle closure disease: prospective observational study.
Change in anterior chamber angle width four weeks after laser peripheral iridotomy in primary angle closure suspects: prospective observational study.
Predictors of persistent raised intraocular pressure twelve weeks after laser peripheral iridotomy in primary angle closure disease: prospective observational study.
Comparison of intraocular pressure reduction after laser peripheral iridotomy between primary angle closure suspects and primary angle closure patients: prospective comparative study.
Change in intraocular pressure three months after cataract surgery in patients with primary angle closure disease and visually significant cataract: prospective observational study.
Association of preoperative anterior chamber depth with intraocular pressure reduction after cataract surgery in primary angle closure disease: prospective observational study.
Comparison of intraocular pressure reduction after cataract surgery between primary angle closure disease and primary open angle glaucoma with cataract: prospective comparative study.
Frequency of immediate intraocular pressure elevation following laser peripheral iridotomy and associated clinical risk factors: prospective observational study.
Change in gonioscopic angle grading after cataract surgery in patients with primary angle closure disease at six weeks: prospective observational study.
Association of lens thickness with postoperative angle widening after cataract surgery in patients with primary angle closure disease: prospective observational study.
Predictors of postoperative intraocular pressure reduction at three months after cataract surgery in patients with coexisting cataract and primary angle closure disease: prospective observational study.
Not the ophthalmology subspeciality you need? Glaucoma is one section of our full ophthalmology collection — the hub page lists every subspeciality, each with its own free topic list. Updated September 2026.
📌 Updated for 2026–2027 MS Ophthalmology Glaucoma admissions
The list was reviewed for feasibility in departments where glaucoma research is based mainly on routine clinic examination, tonometry, gonioscopy, perimetry and optical coherence tomography.
Many topics can be completed with Goldmann applanation tonometry, gonioscopy, optic-disc examination, standard automated perimetry, pachymetry and OCT; specialised imaging is not essential for most resident projects.
Cross-sectional analytical, diagnostic-accuracy, agreement, reliability and short prospective follow-up designs are generally more practical than long-term progression studies requiring several years of observation.
Publication potential is strongest when the protocol defines glaucoma independently of a single test, controls important measurement confounders and distinguishes structural from functional outcomes.
Generate a protocol from any topic above
Select Generate Protocol → beside any title in the list above and receive a submission-ready document built around that topic, containing all eighteen components:
Introduction / Synopsis
Research Question
Aim of the Study
Primary Objective
Secondary Objectives
Materials and Methods
Inclusion Criteria
Exclusion Criteria
Sample Size Calculation
Methodology
Statistical Analysis
Ethical Considerations
Review of Literature
References
Gantt Chart / Study Timeline
Patient Information Sheet
Consent Form
Data Collection Form
Already have your thesis title?
Generate the full glaucoma protocol directly — objectives, methodology, sample size, statistics, timeline, references and annexures.
Alongside glaucoma protocols and synopses, support is also available for departmental presentations, journal club presentations, ethics committee presentations, and posters and oral presentations for medical conferences — for postgraduate residents, board trainees and research scholars across India and the GCC. Prepared by a practising doctor with long experience in medical publishing and thesis supervision.
The topics above work as research questions anywhere — what changes is the document the institution expects, and who approves it before data collection begins. The Gulf equivalent of an Indian synopsis is the glaucoma research proposal submitted to an institutional review board, and it ordinarily carries three sections an Indian synopsis does not: a Gantt chart, a budget and resources section, and a Declaration of Helsinki statement.
Board and residency programmes — country by country
Saudi Arabia — SCFHS and the Saudi Board. Residency and fellowship training under the Saudi Commission for Health Specialties includes a research project with a set timeline, and the glaucoma research proposal is the document prepared at the outset and cleared by the institutional review board before recruitment starts.
United Arab Emirates — DHA, DOH Abu Dhabi and MOHAP. Residents training in Dubai, Abu Dhabi and the northern emirates prepare a glaucoma research protocol for their programme and submit it for institutional review board approval before any data are collected.
Qatar — DHP (formerly QCHP) and Hamad Medical Corporation. A glaucoma IRB proposal is reviewed before recruitment, with the ethics section written to the institution's own template rather than a generic one.
Bahrain — NHRA. Trainees turning glaucoma research topics into a project need the proposal cleared by their institutional research and ethics committee before fieldwork begins.
Oman — OMSB. Residency programmes under the Oman Medical Specialty Board include a research component, and the glaucoma research proposal is the document assessed at the start of it.
Kuwait — KIMS. A glaucoma study protocol goes to the institutional committee for approval before the project begins.
Arab Board programmes across the region. The Arab Board carries its own research requirement irrespective of the host country, and the glaucoma proposal follows the same structure throughout.
Postgraduate degrees — Malaysia, the Gulf and beyond
Malaysia — MMed, the National Medical Research Register and MREC. A glaucoma dissertation proposal for a Master of Medicine programme carried out in a Ministry of Health facility must be registered on the NMRR and approved by the Medical Research and Ethics Committee before the study begins, and the guidance asks for submission four to six months ahead of data collection. Every investigator on the study team registers on the NMRR as well, so the methodology, ethics and team sections are written in far more detail than an Indian synopsis requires.
PhD and Master's candidates elsewhere. University programmes generally require a full glaucoma research proposal of roughly 6,000 to 10,000 words, with an extended literature review, a theoretical framework and a detailed methodology chapter.
PhD and MMed proposals are written individually by a medical doctor and revised until the supervisor accepts them. They are not produced by the automated protocol generator.
Glaucoma research is increasingly focused on earlier detection, structure-function relationships, treatment burden and reproducibility of routine measurements.
OCT-based early glaucoma detection: retinal nerve fibre layer and ganglion cell complex analysis are attractive because structural change may be detectable before advanced field loss, but interpretation must account for axial length, myopia and segmentation artefact.
Angle-closure mechanisms and biometric risk: anterior chamber depth, lens thickness, gonioscopic angle width and response after iridotomy or cataract surgery remain practical areas in populations where angle closure is common.
Visual-field reliability and structure-function correlation: learning effects, fixation losses and false responses can materially alter classification, making reliability itself a clinically useful research area.
Medication burden and ocular surface disease: preserved topical therapy, multiple daily drops, instillation technique and adherence create measurable links between treatment burden, tolerability and pressure control.
Protocol and synopsis guidance
What a Glaucoma protocol must contain
Define glaucoma and the disease category precisely. State how primary open angle glaucoma, primary angle closure disease, ocular hypertension, glaucoma suspect status or secondary glaucoma will be diagnosed. Intraocular pressure alone should not be used as the complete case definition when optic nerve, retinal nerve fibre layer, visual field and angle findings are also relevant.
Standardise each measurement. The protocol should define tonometer, examiner, number of intraocular pressure readings and time of measurement; gonioscopy technique and grading system; visual-field strategy and reliability criteria; and OCT device, scan protocol, signal-quality threshold and rules for segmentation error or repeat scanning.
State the diagnostic or comparison reference clearly. A study comparing van Herick grading with gonioscopy is a diagnostic or agreement question depending on the objective. Similarly, OCT and visual fields measure different domains, so agreement between classifications is not the same as diagnostic accuracy unless an independent reference standard is specified.
Prespecify important confounders. Central corneal thickness can influence measured intraocular pressure, axial length and myopia can affect OCT interpretation, and previous experience can affect visual-field reliability. These factors should be measured or restricted when they can alter the primary outcome.
Glaucoma synopsis versus Glaucoma protocol
The synopsis is the concise study plan. It should identify the glaucoma population, principal exposure or comparison, primary structural or functional outcome, study design and proposed analysis.
The protocol contains the measurement rules. It should specify glaucoma diagnostic criteria, treatment status, study-eye selection, Goldmann applanation technique, pachymetry, gonioscopy method, OCT quality criteria, perimetry reliability limits, masking where relevant and follow-up timing.
Glaucoma studies are especially sensitive to classification errors. A participant may have raised pressure without glaucomatous damage, structural OCT abnormality without a reliable visual-field defect, or advanced field loss despite a clinic pressure within the statistically normal range. The protocol should therefore define how discordant findings will be handled before data collection begins.
Sample size and statistical analysis
Base sample size on the primary glaucoma outcome. Correlation studies use an anticipated correlation coefficient, comparative studies use the expected difference in intraocular pressure, retinal nerve fibre layer thickness or visual-field index, diagnostic-accuracy studies use expected sensitivity or specificity with disease prevalence, and prevalence studies use an expected proportion with chosen precision.
Respect the level at which variables are measured. Visual-field indices, retinal nerve fibre layer thickness and intraocular pressure are eye-level measurements, while adherence, knowledge and quality-of-life scores are usually patient-level. If both eyes are included, the analysis should account for within-person correlation or use a prespecified study-eye rule.
Use statistics that match the question. Correlation does not establish agreement. Tonometry or device-comparison studies require agreement analysis; repeated fields or pressure measurements require reliability or repeated-measures methods; diagnostic studies require sensitivity and specificity against a prespecified reference; and multivariable models should be considered when age, central corneal thickness, axial length, treatment burden or disease severity may confound the principal association.
1. How do I choose a feasible Glaucoma thesis topic?
For 2026–2027 admissions, choose a question that matches the routine patient volume and investigations available in the glaucoma clinic. Primary open angle glaucoma, primary angle closure disease, glaucoma suspects, treated patients and cataract patients undergoing opportunistic screening usually provide more reliable recruitment than uncommon secondary glaucomas. Prefer one clearly defined primary outcome and avoid projects that depend on several years of progression data unless an established longitudinal database already exists.
2. Which study designs are commonly accepted for Glaucoma thesis work?
Common designs include cross-sectional analytical studies, comparative cross-sectional studies, correlation studies, diagnostic-accuracy studies, device-agreement studies, observer-agreement studies, test-retest reliability studies, prospective observational follow-up and retrospective record-based studies. The design should follow the clinical question rather than being selected before the outcome is defined.
3. What should I settle with my guide before finalising a Glaucoma topic?
Settle the glaucoma definition, disease stage, treatment status, study-eye rule, intraocular pressure measurement method and timing, OCT device and quality threshold, visual-field reliability criteria, gonioscopic grading system and primary outcome. If the project is diagnostic, also settle the reference standard before recruitment begins.
4. How should I handle OCT and visual field measurements in Glaucoma research?
Record them as related but distinct structural and functional outcomes. OCT values should be interpreted with attention to scan quality, segmentation error, axial length and myopia. Visual fields should meet prespecified reliability criteria and first-time examinations should be identified because a learning effect can reduce reliability. A study should not label disagreement between OCT and perimetry as measurement error without considering true structure-function discordance.
5. What is the difference between a Glaucoma synopsis and a Glaucoma protocol?
The synopsis summarises the research question, objectives, design, principal measurements and analysis. The protocol provides the operational details, including glaucoma classification, study-eye selection, tonometry technique, pachymetry, gonioscopy, OCT quality rules, visual-field reliability limits, follow-up schedule, observer roles and handling of discordant or missing results.
6. What ethical issues are important in Glaucoma research?
Prospective studies require informed consent, and children or adolescents require guardian consent with age-appropriate assent from about seven years where relevant. Record-based studies may seek a waiver of consent when permitted by the ethics committee. Research should not add unnecessary imaging, provocative testing, medication interruption or treatment delay. Separate consent should be obtained for identifiable ocular photographs or video, and exported OCT or field files should be anonymised. The protocol should define a clinical escalation pathway for incidental findings such as very high intraocular pressure, an occludable angle, advanced previously undiagnosed field loss, progressive optic neuropathy or other findings requiring urgent treatment.
7. Can I use a single visual field test as proof of glaucomatous functional loss?
Usually not without qualification. First-time standard automated perimetry may be affected by learning, fixation losses, false-positive or false-negative responses and fatigue. A protocol should define what constitutes a reliable field and whether an abnormal first examination requires confirmation. If a single field is used because of thesis feasibility, that limitation should be explicit and the study should avoid presenting one unreliable test as definitive functional evidence of glaucoma.
8. Can a Glaucoma thesis also support PhD or Gulf board research pathways?
Yes, but the expected scope differs. A PhD proposal generally requires a broader research gap, stronger methodological justification and a larger programme of work than an MS dissertation. An MS synopsis is usually centred on one feasible dissertation question. SCFHS and Saudi Board trainees may also complete a mandatory board research project, while Arab Board of Health Specializations and DHP, DHA, DOH or MOHAP-linked programmes may use separate research-proposal, ethics and submission pathways. The scientific question can overlap, but the document should be written for the intended programme.
9. When should I register my Glaucoma thesis topic?
Register after confirming adequate case volume, reliable access to tonometry, gonioscopy, perimetry or OCT required by the topic, guide agreement on the glaucoma definition and primary outcome, and a follow-up period that fits the dissertation timeline. Prospective recruitment or research-specific measurements should begin only after the required institutional and ethics approvals are complete.
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